17970
2,4′-Dibromoacetophenone
puriss., ≥98.5% (HPLC)
Synonym(s):
4′-Bromophenacyl bromide
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About This Item
Linear Formula:
BrC6H4COCH2Br
CAS Number:
Molecular Weight:
277.94
Beilstein:
607604
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
grade
puriss.
Assay
≥98.5% (HPLC)
form
solid
mp
108-110 °C (lit.)
108-112 °C
SMILES string
BrCC(=O)c1ccc(Br)cc1
InChI
1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
InChI key
FKJSFKCZZIXQIP-UHFFFAOYSA-N
Gene Information
human ... PLA2G2A(5320)
rat ... Pla2g2a(29692)
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General description
The effect of 2,4′-dibromoacetophenone on rat seminiferous tubules in vitro was studied.
Other Notes
Modifies histidine residues in proteins
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Taomin Huang et al.
Journal of pharmaceutical and biomedical analysis, 41(2), 644-648 (2006-01-18)
A simple, rapid and sensitive high-performance liquid chromatographic method for the simultaneous determination of captopril and hydrochlorothiazide in human plasma samples was developed. Captopril was derivatized with 2,4'-dibromoacetophenone (pBPB) to form a captopril-pBPB adduct. From acidified serum plasma samples, the
J Fohlman et al.
European journal of biochemistry, 94(2), 531-540 (1979-03-01)
Treatment of taipoxin with p-bromophenacyl bromide resulted in modification of single histidine residues in the alpha and beta subunits. The modification decreased the neurotoxicity (lethality) 350-fold, but the inhibitory action on high-affinity choline transport was reduced only threefold. The phospholipase
C H Farr et al.
Journal of reproduction and fertility, 58(1), 37-42 (1980-01-01)
The effects of prostaglandin (PG) F-2 alpha and E-2, cyclic GMP, testosterone and 2,4'-dibromoacetophenone (DBA) on rat seminiferous tubules in vitro were ascertained by measuring contractile frequency, size of contractions and tone (tubular diameter). PGF-2 alpha (10(-9)--10(-5) M) increased frequency
H M Verheij et al.
Biochemistry, 19(4), 743-750 (1980-02-19)
It is known that His-48 is part of the active center in pancreatic phospholipase. To further elucidate the role of histidine-48 in the active center of pancreatic phospholipase A2, we have modified the enzyme with a number of bromo ketones
C C Yang et al.
Biochimica et biophysica acta, 614(2), 373-388 (1980-08-07)
Phospholipase A2 from Naja nigricollis venom was separated into three fractions by chromatography on a column of CM-Sephadex C-25. The pI values of fractions CMS-5, CMS-6 and CMS-9 were determined to be 7.6, 8.3 and 10.6, respectively. Fraction CMS-9 was
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