17970
2,4′-Dibromoacetophenone
puriss., ≥98.5% (HPLC)
Synonym(s):
4′-Bromophenacyl bromide
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About This Item
Linear Formula:
BrC6H4COCH2Br
CAS Number:
Molecular Weight:
277.94
EC Number:
202-783-6
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
607604
MDL number:
Assay:
≥98.5% (HPLC)
Form:
solid
grade
puriss.
assay
≥98.5% (HPLC)
form
solid
mp
108-110 °C (lit.), 108-112 °C
SMILES string
BrCC(=O)c1ccc(Br)cc1
InChI
1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
InChI key
FKJSFKCZZIXQIP-UHFFFAOYSA-N
Gene Information
human ... PLA2G2A(5320)
rat ... Pla2g2a(29692)
General description
The effect of 2,4′-dibromoacetophenone on rat seminiferous tubules in vitro was studied.
Other Notes
Modifies histidine residues in proteins
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Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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Taomin Huang et al.
Journal of pharmaceutical and biomedical analysis, 41(2), 644-648 (2006-01-18)
A simple, rapid and sensitive high-performance liquid chromatographic method for the simultaneous determination of captopril and hydrochlorothiazide in human plasma samples was developed. Captopril was derivatized with 2,4'-dibromoacetophenone (pBPB) to form a captopril-pBPB adduct. From acidified serum plasma samples, the
J Fohlman et al.
European journal of biochemistry, 94(2), 531-540 (1979-03-01)
Treatment of taipoxin with p-bromophenacyl bromide resulted in modification of single histidine residues in the alpha and beta subunits. The modification decreased the neurotoxicity (lethality) 350-fold, but the inhibitory action on high-affinity choline transport was reduced only threefold. The phospholipase
H M Verheij et al.
Biochemistry, 19(4), 743-750 (1980-02-19)
It is known that His-48 is part of the active center in pancreatic phospholipase. To further elucidate the role of histidine-48 in the active center of pancreatic phospholipase A2, we have modified the enzyme with a number of bromo ketones