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18107

2-Methoxyestradiol

purum, ≥98.0% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol

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About This Item

Empirical Formula (Hill Notation):
C19H26O3
CAS Number:
362-07-2
Molecular Weight:
302.41
UNSPSC Code:
51111800
MDL number:
MFCD00010489
Beilstein/REAXYS Number:
3147966
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grade

purum

assay

≥98.0% (HPLC)

storage temp.

−20°C

SMILES string

COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Jamshed H Shah et al.
Bioorganic & medicinal chemistry, 17(20), 7344-7352 (2009-09-19)
A novel series of 17-modified and 2,17-modified analogs of 2-methoxyestradiol (2ME2) were synthesized and characterized. These analogs were designed to retain or potentiate the biological activities of 2ME2 and have diminished metabolic liability. The analogs were evaluated for antiproliferative activity
Lita S Suwandi et al.
Bioorganic & medicinal chemistry letters, 19(22), 6459-6462 (2009-09-29)
The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or improved antitumor activities and reduced metabolic liability compared to
Mathew P Leese et al.
Journal of medicinal chemistry, 51(5), 1295-1308 (2008-02-12)
The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed. 2-Methoxy-17beta-cyanomethylestra-1,3,5(10)-trien-3-ol ( 14), but not the related 2-ethyl derivative 7, and the related 3- O-sulfamates 8 and 15 display potent antiproliferative effects (MCF-7 GI 50
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