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Merck
CN

18248

Sigma-Aldrich

Protein Disulfide Isomerase from bovine liver

≥150 U/mg protein (protein ca. 40%)

Synonym(s):

PDI

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About This Item

CAS Number:
37318-49-3
EC Number:
5.3.4.1 (BRENDA, IUBMB)
MDL number:
MFCD00163364
UNSPSC Code:
12352204

Key Documents

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form

powder
powder with small lumps

specific activity

≥150 U/mg protein (protein ca. 40%)

mol wt

107 kDa by gel filtration
 57 kDa by SDS-PAGE

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C7H5Cl2NO5S/c8-4-2-5(9)6(16(13,14)15-10)1-3(4)7(11)12/h1-2H,10H2,(H,11,12)

InChI key

DHUYKLYJBKXDBM-UHFFFAOYSA-N

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General description

Protein Disulfide Isomerase (PDI) from bovine liver is a homodimer with a molecular weight of 107 kDa (gel filtration) and the molecular weight of the monomer has been reported at 57 kDA (SDS-PAGE). The enzyme is a glycoprotein with 12% total carbohydrate content, composed of 4.6% mannose, 2.5% galactose, 1.4% NANA, and 3.5% 2-acetamido-2-deoxyglucose.

Other Notes

1 unit corresponds to the amount of enzyme, which, in a glutathione-dithiothreitol-system, causes a change of absorbance of 0.001 per minute at pH 4.0 and 25°C.
Enzyme that accelerates the exchange reaction between disulfide bridges in proteins

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Pryank Patel et al.
Journal of molecular biology, 425(5), 929-943 (2013-01-01)
Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal extracellular roles can be attributed to the multidomain structure of AGR2.
Pamela A Wearsch et al.
Methods in molecular biology (Clifton, N.J.), 960, 67-79 (2013-01-19)
The stability of the MHC (major histocompatibility complex) class I peptide repertoire is optimized during assembly in the endoplasmic reticulum (ER) and depends on the collective function of components of the peptide-loading complex (PLC). The chaperone-like molecule tapasin is the
Zegbeh Z Kpadeh et al.
Journal of bacteriology, 195(8), 1825-1833 (2013-02-26)
The extracytoplasmic assembly of the Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide bond (DSB) formation catalyzed by a novel and essential disulfide bond oxidoreductase DsbA2 and not by DsbA1, a second nonessential DSB
Franz-Xaver Kober et al.
The Journal of biological chemistry, 288(3), 2029-2039 (2012-11-30)
About one-third of all cellular proteins pass through the secretory pathway and hence undergo oxidative folding in the endoplasmic reticulum (ER). Protein-disulfide isomerase (PDI) and related members of the PDI family assist in the folding of substrates by catalyzing the
Louise H Boyle et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(9), 3465-3470 (2013-02-13)
Tapasin is an integral component of the peptide-loading complex (PLC) important for efficient peptide loading onto MHC class I molecules. We investigated the function of the tapasin-related protein, TAPBPR. Like tapasin, TAPBPR is widely expressed, IFN-γ-inducible, and binds to MHC
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