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Merck
CN

19330

Cocaine hydrochloride solution

~1 mg/mL in methanol, analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
53-21-4
Molecular Weight:
339.81
UNSPSC Code:
41116107
PubChem Substance ID:
329751841
MDL number:
MFCD00058119

Key Documents

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InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

SMILES string

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI key

PIQVDUKEQYOJNR-VZXSFKIWSA-N

assay

≥98.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

drug control

USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)

concentration

~1 mg/mL in methanol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

~1.2 mL solution

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

General description

Cocaine is mostly commonly available as cocaine hydrochloride which is a white to off-white powder. It is taken by intranasal route. In some surgeries, it is used as topical anaesthetic drug.

Application

It was used as calibration standard to determine cocaine in human hair samples using gas chromatography/mass spectrometry (GC/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

ampoule contains 1.2mL solution

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup - Solvent

flash_point_c

11 °C - closed cup - Solvent

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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L Skender et al.
Forensic science international, 125(2-3), 120-126 (2002-03-23)
Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in
Elena Martín-García et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(10), 2317-2330 (2014-03-19)
High-frequency intake and high drug-induced seeking are associated with cocaine addiction in both human and animals. However, their relationships and neurobiological underpinnings remain hypothetical. The medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and nucleus accumbens (NAc) have been shown to
Billy T Chen et al.
Nature, 496(7445), 359-362 (2013-04-05)
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. Human studies have suggested that deficits in prefrontal cortical function and
John W Muschamp et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), E1648-E1655 (2014-04-08)
Hypocretin (orexin) and dynorphin are neuropeptides with opposing actions on motivated behavior. Orexin is implicated in states of arousal and reward, whereas dynorphin is implicated in depressive-like states. We show that, despite their opposing actions, these peptides are packaged in
Michel C Van den Oever et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(46), 18225-18233 (2013-11-15)
In addicts, associative memories related to the rewarding effects of drugs of abuse can evoke powerful craving and drug seeking urges, but effective treatment to suppress these memories is not available. Detailed insight into the neural circuitry that mediates expression
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