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Merck
CN

21277

Sigma-Aldrich

Calpain Inhibitor I

≥97.0% (TLC)

Synonym(s):

ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al

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About This Item

Empirical Formula (Hill Notation):
C20H37N3O4
CAS Number:
110044-82-1
Molecular Weight:
383.53
Beilstein:
7656053
MDL number:
MFCD00065505
UNSPSC Code:
12352200
PubChem Substance ID:
329752127

Key Documents

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biological source

synthetic

Assay

≥97.0% (TLC)

form

powder

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1

InChI key

FMYKJLXRRQTBOR-BZSNNMDCSA-N

Gene Information

human ... CAPN1(823), CTSB(1508), PSMA1(5682)

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Other Notes

Shows marked inhibition of cathepsin L

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Justyna M Przystal et al.
Molecular oncology, 7(1), 55-66 (2012-09-07)
Bacteriophage (phage), which are viruses that infect bacteria only, have shown promise as vehicles for targeted cancer gene therapy, albeit with poor efficiency. Recently, we generated an improved version of phage vectors by incorporating cis genetic elements of adeno-associated virus
Sayuri Mizukoshi et al.
Experimental eye research, 91(3), 353-361 (2010-06-16)
The present study was performed to investigate changes of cytosolic and mitochondrial calpain activities, and effects of intravitreously injected calpain inhibitor on photoreceptor apoptosis in Royal College of Surgeon's (RCS) rats. Time courses of activities for both cytosolic and mitochondrial
Pedro A Moura et al.
Antimicrobial agents and chemotherapy, 53(12), 4968-4978 (2009-09-16)
Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites. This process, which occurs inside an acidic digestive vacuole (DV), is thought to involve the action of four aspartic proteases, termed plasmepsins (PMs). These enzymes
Byoung-San Moon et al.
Stem cells (Dayton, Ohio), 29(2), 320-331 (2011-07-07)
Sur8/Shoc2 is a scaffold protein that regulates the Ras-extracellular signal-regulated kinase (ERK) pathway. However, the roles of Sur8 in cellular physiologies are poorly understood. In this study, Sur8 was severely repressed in the course of neural progenitor cell (NPC) differentiation
Yadira Bastián et al.
Reproduction (Cambridge, England), 140(5), 673-684 (2010-08-19)
Research on fertilization in mammalian species has revealed that Ca(2+) is an important player in biochemical and physiological events enabling the sperm to penetrate the oocyte. Ca(2+) is a signal transducer that particularly mediates capacitation and acrosome reaction (AR). Before
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