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22690

2,3-Pyridinedicarboxylic acid

Name: 2,3-Pyridinedicarboxylic acid
Brand: SIAL

puriss., ≥99.0% (T)

Synonym(s):

Quinolinic acid

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About This Item

Empirical Formula (Hill Notation):

C₇H₅NO₄

CAS Number:

89-00-9

Molecular Weight:

167.12

PubChem Substance ID:

24853597

UNSPSC Code:

12352100

EC Number:

201-874-8

MDL number:

MFCD00006295

Beilstein/REAXYS Number:

137110

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Properties

grade

puriss.

assay

≥99.0% (T)

ign. residue

≤0.05%

mp

~185 °C (dec.)

SMILES string

OC(=O)c1cccnc1C(O)=O

Gene Information

rat ... Gria1(50592), Grin2a(24409)

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NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.

Sudhir Chowdhry et al.

Nature, 569(7757), 570-575 (2019-04-26)

Precision oncology hinges on linking tumour genotype with molecularly targeted drugs1; however, targeting the frequently dysregulated metabolic landscape of cancer has proven to be a major challenge2. Here we show that tissue context is the major determinant of dependence on