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Merck
CN

23125

Sigma-Aldrich

Chlorambucil

purum, ≥98.0% (T)

Synonym(s):

4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

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About This Item

Empirical Formula (Hill Notation):
C14H19Cl2NO2
CAS Number:
305-03-3
Molecular Weight:
304.21
Beilstein:
999011
EC Number:
206-162-0
MDL number:
MFCD00021783
UNSPSC Code:
12352200
PubChem Substance ID:
329752386

Key Documents

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grade

purum

Assay

≥98.0% (T)

mp

65-70 °C

storage temp.

2-8°C

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

Gene Information

human ... CYP2D6(1565)

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Other Notes

Alkylating antitumor agent, can be covalently coupled to monoclonal anticarcinoembryonic antigen

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335,H350

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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L.G. Bernier et al.
Protides Biol. Fluid Proc. Colloq., 31, 787-787 (1983)
Melissa Millard et al.
Journal of medicinal chemistry, 56(22), 9170-9179 (2013-10-24)
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have higher intrinsic mitochondrial membrane potential (Δψmt) than
Emanuele Zucca et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(5), 565-572 (2013-01-09)
Apart from localized gastric disease, there is no consensus on standard initial treatment of mucosa-associated lymphoid tissue lymphoma. The IELSG-19 study (Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT Lymphoma) was launched to compare chlorambucil alone
Andrew Howman et al.
Lancet (London, England), 381(9868), 744-751 (2013-01-15)
Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves
D Papaioannou et al.
Health technology assessment (Winchester, England), 16(37), 1-253 (2012-10-02)
Follicular lymphoma (FL) is a non-Hodgkin's lymphoma which typically presents when the disease is at an advanced stage. The majority of patients receive first-line therapy of rituximab in combination with chemotherapy, with two-thirds receiving cyclophosphamide, vincristine and prednisolone. The clinical
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