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Merck
CN

23125

Chlorambucil

purum, ≥98.0% (T)

Synonym(s):

4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

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About This Item

Empirical Formula (Hill Notation):
C14H19Cl2NO2
CAS Number:
305-03-3
Molecular Weight:
304.21
EC Number:
206-162-0
UNSPSC Code:
12352200
PubChem Substance ID:
329752386
Beilstein/REAXYS Number:
999011
MDL number:
MFCD00021783

Key Documents

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InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

grade

purum

assay

≥98.0% (T)

mp

65-70 °C

storage temp.

2-8°C

Gene Information

human ... CYP2D6(1565)

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Other Notes

Alkylating antitumor agent, can be covalently coupled to monoclonal anticarcinoembryonic antigen

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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B Cortés et al.
Dermatology (Basel, Switzerland), 225(4), 320-325 (2012-12-22)
Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease and is associated with an increased mortality. The end points of our study were to evaluate the mortality rate in a retrospective cohort of BP patients followed up to
L.G. Bernier et al.
Protides Biol. Fluid Proc. Colloq., 31, 787-787 (1983)
Emanuele Zucca et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(5), 565-572 (2013-01-09)
Apart from localized gastric disease, there is no consensus on standard initial treatment of mucosa-associated lymphoid tissue lymphoma. The IELSG-19 study (Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT Lymphoma) was launched to compare chlorambucil alone
Melissa Millard et al.
Journal of medicinal chemistry, 56(22), 9170-9179 (2013-10-24)
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have higher intrinsic mitochondrial membrane potential (Δψmt) than
Andrew Howman et al.
Lancet (London, England), 381(9868), 744-751 (2013-01-15)
Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves
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