23182
(+)-1-(9-Fluorenyl)ethyl chloroformate solution
≥18 mM in acetone, derivatization grade (chiral), LiChropur™
Synonym(s):
(+)-FLEC solution
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About This Item
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
Molecular Weight:
272.73
UNSPSC Code:
41115716
PubChem Substance ID:
NACRES:
NA.22
MDL number:
grade
derivatization grade (chiral)
Quality Segment
product line
ChiraSelect™
optical purity
enantiomeric ratio: ≥99.0:1.0 (HPLC)
quality
LiChropur™
concentration
≥18 mM in acetone
technique(s)
HPLC: suitable
refractive index
n20/D 1.359
storage temp.
2-8°C
SMILES string
ClC(=O)OC(C1c2c(cccc2)c3c1cccc3)C
InChI
1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3
InChI key
SFRVOKMRHPQYGE-UHFFFAOYSA-N
General description
(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.
Application
(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.
Physical form
solution, 5 mg in 1 mL acetone
Other Notes
Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity
Legal Information
ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
1.4 °F
flash_point_c
-17 °C
Regulatory Information
危险化学品
易制毒化学品（3类）
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Zeineb Aturki et al.
Electrophoresis, 25(4-5), 607-614 (2004-02-26)
The indirect resolution of five beta-adrenoreceptor blocking agents (propranolol, oxprenolol, pindolol, metoprolol, and atenolol) using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and capillary electrochromatography (CEC) is reported. Three octadecylsilanized (ODS) silica gel-based stationary phases, differing in particle diameter and carbon
A Roux et al.
Journal of chromatography, 570(2), 453-461 (1991-10-04)
A method for the determination of the R-(+) and S-(-) enantiomers of propranolol in blood was developed. After extraction with heptane-isopentanol and derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate, excess reagent was removed using solid-phase extraction. The enantiomers were separated on an achiral
Michelle A Camerino et al.
Organic & biomolecular chemistry, 11(16), 2571-2573 (2013-03-14)
An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 23182-10X1ML-F | 04061838082374 |
| 23182-1ML-F-KC | 04061838039156 |
| 23182-10ML-F | 04061838082367 |