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(+)-1-(9-Fluorenyl)ethyl chloroformate solution

≥18 mM in acetone, for chiral derivatization, LiChropur™

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Synonym(s):
(+)-FLEC solution
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
107474-79-3
Molecular Weight:
272.73
MDL number:
MFCD00043429
PubChem Substance ID:
329752390
NACRES:
NA.22

grade

for chiral derivatization

Quality Level

100

product line

ChiraSelect™

optical purity

enantiomeric ratio: ≥99.0:1.0 (HPLC)

quality

LiChropur™

concentration

≥18 mM in acetone

technique(s)

HPLC: suitable

refractive index

n20/D 1.359

storage temp.

2-8°C

InChI

1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3

InChI key

SFRVOKMRHPQYGE-UHFFFAOYSA-N

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General description

(+)-1-(9-Fluorenyl)ethyl chloroformate [(+)-FLEC] is a chiral derivatizing reagent. It helps in separating enantiomers of α-amino acids, as well as helps in determining its optical purity using HPLC method.

Application

(+)-FLEC may be used in enantioselective analysis of glufosinate using reversed-phase high-performance liquid chromatography system coupled with a fluorescence detection system.

Physical form

solution, 5 mg in 1 mL acetone

Other Notes

Chiral derivatizing agent for primary and secondary amino acids and amines. The derivatives are separated by reversed-phase LC with fluorescence detection for determining the enantiomeric purity

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225 - H319 - H336

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

1.4 °F

Flash Point(C)

-17 °C

Regulatory Information

危险化学品
易制毒化学品（3类）

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Separation of enantiomers of a-hydroxy acids by reversed-phase liquid chromatography after derivatization with 1-(9-fluorenyl) ethyl chloroformate.
Fransson, Bengt, and Ulf Ragnarsson.
Journal of Chromatography A, 827, 31-36 (1998)
Identifying the carboxy terminal amino acid of a protein.
T H Akiyama et al.
Methods in molecular biology (Clifton, N.J.), 64, 235-242 (1997-01-01)
E Frigerio et al.
Journal of chromatography. A, 660(1-2), 351-358 (1994-02-04)
A sensitive and selective high-performance liquid chromatographic method for the determination of reboxetine enantiomers in human plasma was developed. Although two chiral centres are present in reboxetine, its stereospecific synthesis leads to two rather than four possible enantiomers. After extraction
N Todoroki et al.
Journal of chromatography. B, Biomedical sciences and applications, 728(1), 41-47 (1999-06-24)
The natural occurrence of N-methyl-D-aspartate (NMDA) is limited to the foot muscle of Scapharca broughtonii; it is a well known compound for its neuroexitatory activity. This paper describes a high-performance liquid chromatographic (HPLC) method for the determination of NMDA in
Michelle A Camerino et al.
Organic & biomolecular chemistry, 11(16), 2571-2573 (2013-03-14)
An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral
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