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Merck
CN

24367

2-Chloro-N,N-dimethylpropylamine hydrochloride

purum, ≥97.0% (AT)

Synonym(s):

β-(Dimethylamino)isopropyl chloride hydrochloride, 2-(Dimethylamino)isopropyl chloride hydrochloride, 2-Chloro-1-(dimethylamino)propane hydrochloride, N-(2-Chloropropyl)dimethylamine hydrochloride

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About This Item

Linear Formula:
CH3CHClCH2N(CH3)2 · HCl
CAS Number:
4584-49-0
Molecular Weight:
158.07
EC Number:
224-971-7
UNSPSC Code:
12352100
PubChem Substance ID:
24854630
Beilstein/REAXYS Number:
3670215
MDL number:
MFCD00012534

Key Documents

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grade

purum

assay

≥97.0% (AT)

mp

187-190 °C

solubility

methanol: soluble 1 g/10 mL, clear, colorless

SMILES string

Cl.CC(Cl)CN(C)C

InChI

1S/C5H12ClN.ClH/c1-5(6)4-7(2)3;/h5H,4H2,1-3H3;1H

InChI key

OCWGRWAYARCRTQ-UHFFFAOYSA-N

Application

2-Chloro-N,N-dimethylpropylamine hydrochloride was used in the synthesis of 6-substituted 8,9-dimethoxy-2,3-methylenedioxy-6H-dibenzo[c,h][2,6]naphthyridin-5-ones.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Shejin Zhu et al.
Bioorganic & medicinal chemistry, 14(9), 3131-3143 (2006-01-18)
6-Substituted 8,9-dimethoxy-2,3-methylenedioxy-6H-dibenzo[c,h][2,6]naphthyridin-5-ones were synthesized and evaluated for topoisomerase I-targeting activity and cytotoxicity. Several of these reversed lactam analogues of ARC-111 exhibited exceptional cytotoxicity with IC50 values ranging from 0.5 to 3.0 nM. In contrast to topotecan, no resistance was observed

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