25745
Chloroquine diphosphate salt
≥96.0% (TLC)
Synonym(s):
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
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About This Item
Empirical Formula (Hill Notation):
C18H26ClN3 · 2H3PO4
CAS Number:
Molecular Weight:
515.86
EC Number:
200-055-2
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
4223142
assay
≥96.0% (TLC)
impurities
≤3% water
solubility
H2O: 50 mg/mL, clear
mode of action
enzyme | inhibits
SMILES string
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChI key
QKICWELGRMTQCR-UHFFFAOYSA-N
Other Notes
Lysosomotropic drug
This product has been replaced by C6628-SIGMA | Chloroquine diphosphate salt solid, ≥98%
Regulatory Information
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D.D. Hong
Anal. Profiles Drug Subst., 5, 61-61 (1976)
Rebecca A Clewell et al.
Toxicology and applied pharmacology, 237(3), 366-374 (2009-04-28)
Chloroquine (CQ), a drug that has been used extensively for the prevention and treatment of malaria, is currently considered safe for use during pregnancy. However, CQ has been shown to disrupt steroid homeostasis in adult rats and similar compounds, such
Ingeborg Walter-Sack et al.
European journal of clinical pharmacology, 65(2), 179-189 (2008-09-24)
Methylene blue (MB) has recently been reevaluated for malaria treatment. With the aim of excluding treatment failures due to low bioavailability, we have investigated the absolute bioavailability of MB given as an aqueous oral formulation and its interaction with chloroquine