26370
N-Chlorosuccinimide
purum, ≥96.0% (RT)
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About This Item
Empirical Formula (Hill Notation):
C4H4ClNO2
CAS Number:
Molecular Weight:
133.53
EC Number:
204-878-8
UNSPSC Code:
12352101
MDL number:
Beilstein/REAXYS Number:
113915
grade
purum
assay
≥96.0% (RT)
mp
148-150 °C
SMILES string
ClN1C(=O)CCC1=O
InChI
1S/C4H4ClNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
InChI key
JRNVZBWKYDBUCA-UHFFFAOYSA-N
Other Notes
Versatile chlorinating and oxidizing agent; antibacterial 2;
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Y Shechter et al.
Biochemistry, 15(23), 5071-5075 (1976-11-16)
Tryptophanyl peptide bonds are selectively cleaved by N-chlorosuccinimide (NCS) under acidic conditions. All other peptide bonds are resistant to cleabage by this reagent. Optimal conditions for cleavage are: 2 equiv of NCS, pH 4-5, or 50-80% acetic acid for 30
Chemical modification studies on the Ca2+-dependent protein modulator of cyclic nucleotide phosphodiesterase.
M Walsh et al.
Biochemistry, 16(12), 2742-2749 (1977-06-14)
Shiv Gandhi et al.
Cell chemical biology, 27(11), 1410-1424 (2020-09-06)
Rhomboid intramembrane proteases regulate pathophysiological processes, but their targeting in a disease context has never been achieved. We decoded the atypical substrate specificity of malaria rhomboid PfROM4, but found, unexpectedly, that it results from "steric exclusion": PfROM4 and canonical rhomboid