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Merck
CN

27043

Sigma-Aldrich

Chondroitin 6-sulfate sodium salt from shark cartilage

Synonym(s):

Chondroitin sulfate C sodium salt, Poly[β-glucuronic acid-(1→3)-N-acetyl-β-galactosamine-6-sulfate-(1→4)] alternating

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About This Item

CAS Number:
12678-07-8
UNSPSC Code:
12352201

Key Documents

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optical activity

[α]20/D −15±5°, c = 1% in H2O

impurities

~3% total nitrogen (N)
~7% total S

loss

≤10% loss on drying

solubility

H2O: 10 mg/mL, clear, colorless

suitability

suitable as substrate for chondroitinase test

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Application

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.

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G Cilpa et al.
The journal of physical chemistry. B, 115(16), 4818-4825 (2011-04-05)
A force field has been previously designed for a dodecasaccharide chain of chondroitin-6-sulfate (C6S) and has proved to yield valuable data going from basic conformational properties to a more detailed H-bonding network. This force field is further used here to
Katriina Lipponen et al.
Analytical chemistry, 83(15), 6040-6046 (2011-06-10)
Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan. The techniques employed were
Antonella Sgambato et al.
Molecules (Basel, Switzerland), 25(19) (2020-09-27)
The regeneration of the nervous system is a challenging task. Currently, regenerative medicine approaches that exploit nature-inspired cues are being studied and hold great promise. The possibility to use protein-based matrices functionalized with small oligo- and monosaccharides is of interest
Karla L Miller et al.
Rheumatic diseases clinics of North America, 37(1), 103-118 (2011-01-12)
Glucosamine and chondroitin sulfate, components of normal cartilage that are marketed as dietary supplements in the United States, have been evaluated for their potential role in the treatment of osteoarthritis. Due to claims of efficacy, increased prevalence of osteoarthritis, and
Clare M Galtrey et al.
Brain research reviews, 54(1), 1-18 (2007-01-16)
Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein and glycosaminoglycan (GAG) chains. There is enormous structural diversity among CSPGs due to variation in the core protein, the number of GAG chains and the extent and position of sulfation. Most
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