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Merck
CN

27242

Sigma-Aldrich

Trichloroacetic acid

puriss., meets analytical specification of Ph. Eur., USP 21, 99-100.5% (calc. to the dried substance)

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
76-03-9
Molecular Weight:
163.39
Beilstein:
970119
EC Number:
200-927-2
MDL number:
MFCD00004177
UNSPSC Code:
12352100
PubChem Substance ID:
57648227
NACRES:
NA.21

Key Documents

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vapor density

<1 (vs air)

Quality Level

200

vapor pressure

1 mmHg ( 51 °C)

grade

puriss.

Assay

99-100.5% (calc. to the dried substance)

quality

meets analytical specification of Ph. Eur., USP 21

ign. residue

≤0.02% (as SO4)

loss

≤0.5% loss on drying, 18 h (on silica gel)

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

soluble 81.7 g/L at 20 °C (completely)

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Fe: ≤20 mg/kg

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.
Trichloroacetic acid may be used in catalytic amounts to enhance the yield of benzenediazonium-2-carboxylate from anthranilic acid.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H314,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

>235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
STBJ5122
STBJ4233
STBJ3475
STBH7097
STBJ1433

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Benzenediazonium-2-Carboxylate and Biphenylene.
Logullo FM, et al
Organic Syntheses, 5, 54-54 (1973)
Solubility of albumin in alcohol after precipitation by trichloroacetic acid: a simplified procedure for separation of albumin.
J R DEBRO et al.
Nature, 178(4541), 1067-1067 (1956-11-10)
A microcolorimetric method for the determination of inorganic phosphorus.
H H TAUSSKY et al.
The Journal of biological chemistry, 202(2), 675-685 (1953-06-01)
S L Herren-Freund et al.
Toxicology and applied pharmacology, 90(2), 183-189 (1987-09-15)
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic
Inga Müller et al.
PloS one, 9(5), e97285-e97285 (2014-05-27)
Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with MYCN-amplified neuroblastoma have a poor prognosis, targeting MYCN using small molecule inhibitors
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