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Merck
CN

27242

Trichloroacetic acid

puriss., meets analytical specification of Ph. Eur., USP 21, 99-100.5% (calc. to the dried substance)

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
76-03-9
Molecular Weight:
163.39
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57648227
EC Number:
200-927-2
Beilstein/REAXYS Number:
970119
MDL number:
MFCD00004177

Key Documents

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Product Name

Trichloroacetic acid, puriss., meets analytical specification of Ph. Eur., USP 21, 99-100.5% (calc. to the dried substance)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(=O)C(Cl)(Cl)Cl

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

grade

puriss.

assay

99-100.5% (calc. to the dried substance)

quality

meets analytical specification of Ph. Eur., USP 21

ign. residue

≤0.02% (as SO4)

loss

≤0.5% loss on drying, 18 h (on silica gel)

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

soluble 81.7 g/L at 20 °C (completely)

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Fe: ≤20 mg/kg

Quality Level

200

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Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.
Trichloroacetic acid may be used in catalytic amounts to enhance the yield of benzenediazonium-2-carboxylate from anthranilic acid.

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H314,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
STBJ5122
STBJ4233
STBJ3475
STBH7097
STBJ1433

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Benzenediazonium-2-Carboxylate and Biphenylene.
Logullo FM, et al
Organic Syntheses, 5, 54-54 (1973)
Solubility of albumin in alcohol after precipitation by trichloroacetic acid: a simplified procedure for separation of albumin.
J R DEBRO et al.
Nature, 178(4541), 1067-1067 (1956-11-10)
A microcolorimetric method for the determination of inorganic phosphorus.
H H TAUSSKY et al.
The Journal of biological chemistry, 202(2), 675-685 (1953-06-01)
S L Herren-Freund et al.
Toxicology and applied pharmacology, 90(2), 183-189 (1987-09-15)
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic
Ying Wang et al.
Diabetes, 63(8), 2643-2655 (2014-03-13)
After diabetes, the heart has a singular reliance on fatty acid (FA) for energy production, which is achieved by increased coronary lipoprotein lipase (LPL) that breaks down circulating triglycerides. Coronary LPL originates from cardiomyocytes, and to translocate to the vascular
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