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Merck
CN

27963

Sigma-Aldrich

Castor Oil, Ethoxylated

Synonym(s):

Cremophor® EL, EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12161900
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description

non-ionic

density

1.05 g/mL at 20 °C

application(s)

sample preservation

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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Other Notes

A derivative of castor oil and ethylene oxide.
This product has been replaced by C5135-SIGMA | Kolliphor EL pH-range 6.0 - 8.0

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

494.6 °F - Not applicable

Flash Point(C)

257 °C - Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Allergic contact dermatitis to polyethylene glycol-7 hydrogenated castor oil.
M Kalavala et al.
Contact dermatitis, 56(5), 287-288 (2007-04-20)
William J Gradishar et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(31), 7794-7803 (2005-09-21)
ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was compared with polyethylated castor oil-based standard paclitaxel in patients with metastatic breast cancer (MBC). This phase III study was performed to confirm preclinical studies demonstrating
Nuhad K Ibrahim et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(5), 1038-1044 (2002-05-15)
ABI-007 is a novel Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. The absence of Cremophor EL may permit ABI-007 to be administered without the premedications used routinely for the prevention of hypersensitivity reactions. Furthermore, this novel formulation permits a higher paclitaxel
K Itoh et al.
International journal of pharmaceutics, 246(1-2), 75-83 (2002-09-25)
The optimized formulation of N-4472, N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-[4-(N-benzylpiperidyl)] urea, which was a poorly water-soluble drug, was developed by utilizing the complexation between N-4472 and L-ascorbic acid (VC). It was found that the formulation with Gelucire((R)) 44/14, HCO-60((R)) and sodium dodecyl sulfate provided
Jessica M Jones et al.
eLife, 9 (2020-08-08)
Objective and automatic measurement of pain in mice remains a barrier for discovery in neuroscience. Here, we capture paw kinematics during pain behavior in mice with high-speed videography and automated paw tracking with machine and deep learning approaches. Our statistical

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