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Merck
CN

28244

Ethyl cellulose

tested according to Ph. Eur., viscosity 10 mPa.s 

Synonym(s):

Ethylcellulosum

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About This Item

CAS Number:
9004-57-3
UNSPSC Code:
12352200
MDL number:
MFCD00131037

Key Documents

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agency

USP/NF, tested according to Ph. Eur.

form

coarse powder

autoignition temp.

698 °F

concentration

48.0-49.5% (Ethoxy (OC2H5) groups (dried substances)- EU Portal, GC)

refractive index

n20/D 1.47 (lit.)

viscosity

10 mPa.s

solubility

acetone: soluble, benzene: soluble, butyl acetate: soluble, carbon tetrachloride: soluble, ethanol: soluble, glycerol: insoluble, propylene glycol: insoluble, water: insoluble, xylene: soluble

density

1.14 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

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General description

Ethyl cellulose is a lipophilic polymer that possesses excellent membrane-forming ability and durability. It facilitates the formation of free films and is utilized in studying the dynamic interaction of polymer films with water.

Application

Ethyl cellulose has been used in the preparation of biostructures such as matrices, microspheres, microparticles, pellets and tablets for use in drug delivery. It has also been used in making chemically modified ethyl cellulose-based membrane for the purification of IgG.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBQ4872V

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A Martinac et al.
International journal of pharmaceutics, 291(1-2), 69-77 (2005-02-15)
Loratadine-loaded microspheres were prepared by spray-drying of dispersions, emulsions and suspensions differing in polymeric composition and solvents used. Conventional microspheres were obtained by spray-drying of dispersions composed of chitosan (CM) as only polymer, while composed microspheres were obtained by spray-drying
Anna Jansson et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 20(2), 394-406 (2014-02-26)
Drug release from oral pharmaceutical formulations can be modified by applying a polymeric coating film with controlled mass transport properties. Interaction of the coating film with water may crucially influence its composition and permeability to both water and drug. Understanding
Syed Umer Jan et al.
Pakistan journal of pharmaceutical sciences, 25(4), 751-756 (2012-09-27)
The aim and objective of the present study was to formulate and evaluate controlled release polymeric tablets of ibuprofen with determinations of formulation factors using various grades and types of polymer ethocel i.e. ethocel standard 10P; 10FP, 100P and100FP for
Nahla S Barakat et al.
Drug development and industrial pharmacy, 39(2), 352-362 (2012-05-01)
Gliclazide (GLZ)-loaded microparticles made with a polymeric blend were prepared by a solvent evaporation technique. Organic solutions of two polymers, poly(ε-caprolactone) (PCL) and Eudragit RS (E RS) or ethyl cellulose (EC), in different weight ratios, and 33.3% of GLZ were
Xin Li et al.
Die Pharmazie, 67(8), 695-700 (2012-09-11)
A novel osmotic pump tablet with ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) as the semipermeable membrane and isosorbide-5-mononitrate (5-ISMN) as the model drug was formulated in this study. Zero order release kinetics were attained by avoiding aging during storage.
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