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Merck
CN

292664

N-tert-Butyl-α-(2-sulfophenyl)nitrone sodium salt

95%

Synonym(s):

2-SPBN sodium salt, 2-Sulfonatophenyl tert-butyl nitrone sodium salt

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About This Item

Linear Formula:
NaO3SC6H4CH=N(O)C(CH3)3
CAS Number:
Molecular Weight:
279.29
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
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InChI

1S/C11H15NO4S.Na/c1-11(2,3)12(13)8-9-6-4-5-7-10(9)17(14,15)16;/h4-8H,1-3H3,(H,14,15,16);/q;+1/p-1/b12-8-;

SMILES string

[Na+].CC(C)(C)[N+](\[O-])=C\c1ccccc1S([O-])(=O)=O

InChI key

LAIQBHGUFDAJKL-JCTPKUEWSA-M

assay

95%

form

powder or crystals

mp

246 °C (dec.) (lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Application

Water-soluble, negatively-charged spin trap used to monitor aqueous phase of SDS micelles.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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G J Wilde et al.
Journal of neurochemistry, 69(2), 883-886 (1997-08-01)
The relative roles of the superoxide and hydroxyl radicals in oxidative stress-induced neuronal damage were investigated using organotypic hippocampal slice cultures. Cultures exposed to 100 microM duroquinone, a superoxide-generating compound, for 3 h developed CA1-selective lesions over a period of
Maria Molnar et al.
Upsala journal of medical sciences, 115(3), 163-168 (2010-07-20)
Hyperglycemia exacerbates focal ischemic brain damage supposedly through various mechanisms. One such mechanism is oxidative stress involving reactive oxygen and nitrogen species (RONS) production. Nitrones attenuate oxidative stress in various models of brain injury. Sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) can be
Catherine E Hobbs et al.
Pediatrics international : official journal of the Japan Pediatric Society, 50(4), 481-488 (2008-10-22)
The production of oxygen free radicals after perinatal hypoxia-ischemia is thought to play a critical role in the pathogenesis of the brain injury. Administration of anti-oxidants may thus be neuroprotective. The aim of the present study was to investigate the
Steven L Peterson et al.
Neurotoxicology, 26(6), 969-979 (2005-05-14)
The status epilepticus (SE) induced in rats by lithium-pilocarpine (Li-pilo) shares many common features with soman-induced SE including extensive limbic neuropathology. Reactive oxygen species are hypothesized to play a role in the SE induced neuropathology and we propose that the
B Ferger et al.
European journal of pharmacology, 360(2-3), 155-163 (1998-12-16)
The potential new iron-chelator cytisine and the radical scavenger N-tert-butyl-alpha-(2-sulfophenyl) nitrone (S-PBN) were incubated in a Fenton system and hydroxyl radical formation was measured with the salicylate trapping assay. Both cytisine and S-PBN reduced hydroxyl radical formation in a concentration-dependent

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