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Merck
CN

32152

Supelco

Parecoxib

VETRANAL®, analytical standard

Synonym(s):

N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide, N-{[4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl]sulfonyl}propionamide

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About This Item

Empirical Formula (Hill Notation):
C19H18N2O4S
CAS Number:
198470-84-7
Molecular Weight:
370.42
Beilstein:
8640266
MDL number:
MFCD08141856
UNSPSC Code:
41116107
PubChem Substance ID:
329754072
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

product line

VETRANAL®

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CCC(=O)NS(=O)(=O)c1ccc(cc1)-c2c(C)onc2-c3ccccc3

InChI

1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)

InChI key

TZRHLKRLEZJVIJ-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd,H373

Hazard Classifications

Repr. 2 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF1595
BCCD4051
BCBW2257
BCBS0811V

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Jie Hu et al.
BioMed research international, 2020, 1563874-1563874 (2020-08-25)
A sensitive and reliable ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous determination of parecoxib and its metabolite valdecoxib in beagles. The effects of dexmedetomidine on the pharmacokinetics of parecoxib and valdecoxib in beagles were
Lin-Yong Li et al.
Biology open, 6(3), 311-316 (2016-11-30)
Glioblastoma (GBM) is one of the most lethal brain cancers worldwide, and there is an urgent need for development of novel therapeutic approaches. Parecoxib is a well-known cyclooxygenase-2 (COX-2) inhibitor, and had already been developed for postoperative analgesia with high
Yi Tian et al.
Journal of orthopaedic surgery and research, 15(1), 41-41 (2020-02-08)
Total knee arthroplasty (TKA) is usually associated with moderate to severe postoperative pain. Peripheral nerve block (PNB) and local infiltration analgesia (LIA) are two major methods for postoperative analgesia. Femoral nerve block (FNB) leads to residual posterior knee pain; thus
Ippokratis Pountos et al.
Journal of cellular and molecular medicine, 15(3), 525-534 (2010-01-15)
The non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for analgesia but may inhibit bone formation. We investigated whether the reported NSAID effect on bone is related to inhibition of bone marrow mesenchymal stem cell (MSC) proliferation and osteogenic and chondrogenic
Bo Wang et al.
BMC anesthesiology, 17(1), 152-152 (2017-11-15)
Previous studies have shown that cyclooxygenase-2, a key enzyme that converts arachidonic acid to prostaglandins, is involved in anxiety and cognitive processes, but few studies have investigated the effects of chronic administration of cyclooxygenase-2 inhibitors on anxiety, learning and memory
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