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Merck
CN

32236

Firocoxib

VETRANAL®, analytical standard

Synonym(s):

3-Cyclopropylmethoxy-4-(4-methanesulfonylphenyl)-5,5-dimethyl-5H-furan-2-one

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About This Item

Empirical Formula (Hill Notation):
C17H20O5S
CAS Number:
189954-96-9
Molecular Weight:
336.40
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754109
MDL number:
MFCD09837800
Beilstein/REAXYS Number:
8335837

Key Documents

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InChI

1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3

SMILES string

O=S(C1=CC=C(C2=C(OCC3CC3)C(OC2(C)C)=O)C=C1)(C)=O

InChI key

FULAPETWGIGNMT-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP3462
BCCM9523
BCCK3367
BCCF6251
BCBX0038

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M L Stock et al.
Journal of veterinary pharmacology and therapeutics, 37(5), 457-463 (2014-04-09)
The objective of this study was to determine the pharmacokinetics of intravenous and oral firocoxib in 10 healthy preweaned calves. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14-day washout period, animals received firocoxib orally prior to
Michèle Y Doucet et al.
Journal of the American Veterinary Medical Association, 232(1), 91-97 (2008-01-03)
To compare efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. Randomized controlled clinical trial. 253 client-owned horses with naturally occurring osteoarthritis. Horses were treated with firocoxib (0.1 mg/kg [0.045 mg/lb], PO, q
Curtis J Cathcart et al.
American journal of veterinary research, 73(1), 19-26 (2011-12-30)
To investigate the ability of ABT-116 (a proprietary antagonist of transient receptor potential vanilloid type 1) administered at 2 doses to attenuate lameness in dogs with experimentally induced urate synovitis. 8 purpose-bred mixed-breed dogs. In a 4-way crossover study, dogs
D W Knapp et al.
Journal of veterinary internal medicine, 27(1), 126-133 (2012-12-05)
Cisplatin combined with a nonselective cyclooxygenase (cox) inhibitor has potent antitumor activity against transitional cell carcinoma (TCC) in dogs, but this treatment is limited by renal toxicosis. Cox-2 is expressed in TCC, but only in limited sites within the kidney.
Janaina B Camargo et al.
Veterinary anaesthesia and analgesia, 38(3), 252-259 (2011-04-16)
To compare the post-operative analgesic effects of butorphanol or firocoxib in dogs undergoing ovariohysterectomy. Prospective, randomized, blinded, clinical trial. Twenty-five dogs >1 year of age. Dogs received acepromazine intramuscularly (IM), 0.05 mg kg(-1) and either butorphanol IM, 0.2 mg kg(-1)
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