32492
Florfenicol amine
VETRANAL®, analytical standard
Synonym(s):
(αR)-α-[(1S)-1-Amino-2-fluoroethyl]-4-(methylsulfonyl)benzenemethanol, D-(−)-threo-2-Amino-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol
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About This Item
Empirical Formula (Hill Notation):
C10H14FNO3S
CAS Number:
Molecular Weight:
247.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C10H14FNO3S/c1-16(14,15)8-4-2-7(3-5-8)10(13)9(12)6-11/h2-5,9-10,13H,6,12H2,1H3/t9-,10-/m1/s1
SMILES string
CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@H](N)CF
InChI key
XLSYLQDVLAXIKK-NXEZZACHSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Related Categories
General description
Florfenicol amine is a polar metabolite of florfenicol.
Application
Florfenicol amine may be used as an analytical reference standard for the determination of the analyte in:
- Poultry and porcine muscle and liver by gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS) with selected ion monitoring (SIM) detection.
- Food samples by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) operating in selected reaction monitoring (SRM) detection mode.
- Chicken muscle by LC-ESI-MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
涉药品监管产品
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Pengjie Luo et al.
Journal of AOAC International, 92(3), 981-988 (2009-07-21)
A sensitive and heterologous enzyme-linked immunosorbent assay (ELISA) for the simultaneous detection of florfenicol (FF) and its metabolite florfenicol amine (FFA) in swine muscle tissue was developed. FFA was conjugated to bovine serum albumin by a formaldehyde coupling method as
Arturo Anadón et al.
Journal of agricultural and food chemistry, 56(22), 11049-11056 (2008-11-04)
Chickens were used to investigate plasma disposition of florfenicol after single intravenous (i.v.) and oral dose (20 mg kg-1 body weight) and to study residue depletion of florfenicol and its major metabolite florfenicol-amine after multiple oral doses (40 mg kg-1
V Hormazabal et al.
Journal of chromatography, 616(1), 161-165 (1993-06-23)
A simple and rapid high-performance liquid chromatographic method for the simultaneous extraction and determination of residues of florfenicol and its metabolite florfenicol amine in fish tissue, muscle and liver has been developed. The calibration curves were linear, the recovery of
Jiancheng Li et al.
Journal of agricultural and food chemistry, 54(25), 9614-9619 (2006-12-07)
A study of the tissue depletion of florfenicol (FF) administered intramuscularly twice to swine at a dose rate of 20 mg per kg of body weight at 24 h intervals was carried out. Forty healthy cross swine were treated with
B-K Park et al.
Journal of veterinary pharmacology and therapeutics, 30(1), 32-36 (2007-01-16)
The pharmacokinetics of florfenicol and its active metabolite florfenicol amine were investigated in rabbits after a single intravenous (i.v.) and oral (p.o.) administration of florfenicol at 20 mg/kg bodyweight. The plasma concentrations of florfenicol and florfenicol amine were determined simultaneously
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