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Merck
CN

32570

N,N-Diethyl-3-methylbenzamide

purum, ≥95.0% (GC)

Synonym(s):

N,N-Diethyl-m-toluamide, m-Toluic acid diethylamide, DEET

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About This Item

Linear Formula:
CH3C6H4CON(C2H5)2
CAS Number:
134-62-3
Molecular Weight:
191.27
EC Number:
205-149-7
UNSPSC Code:
12352100
PubChem Substance ID:
24859526
Beilstein/REAXYS Number:
2046711
MDL number:
MFCD00009046

Key Documents

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vapor density

6.7 (vs air)

vapor pressure

<0.01 mmHg ( 25 °C)

grade

purum

assay

≥95.0% (GC)

refractive index

n20/D 1.523

bp

111 °C/1 mmHg, 160 °C/19 mmHg (lit.)

density

0.998 g/mL at 20 °C (lit.)

SMILES string

CCN(CC)C(=O)c1cccc(C)c1

InChI

1S/C12H17NO/c1-4-13(5-2)12(14)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3

InChI key

MMOXZBCLCQITDF-UHFFFAOYSA-N

General description

N,N-Diethyl-3-methylbenzamide (DEET) is an all-purpose topical insect repellent and its pharmacokinetics, formulation and safety aspects were discussed. DEET was reported to kill cercariae of Schistosoma mansoni in vitro. DEET is a potent cercariacide and an effective agent at preventing cercarial penetration into treated mouse tail skin.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

203.0 °F - closed cup

flash_point_c

95 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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W E Secor et al.
The American journal of tropical medicine and hygiene, 60(6), 1061-1062 (1999-07-14)
N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine
Daniel L Sudakin et al.
Journal of toxicology. Clinical toxicology, 41(6), 831-839 (2003-12-18)
The emergence of West Nile Virus (WNV) in North America has resulted in increased public awareness and utilization of insect repellents containing N,N-diethyl-m-toluamide (DEET) in the prevention of mosquito-borne disease. Regulatory reassessments in North American countries have recently been completed
T G Osimitz et al.
Journal of toxicology. Clinical toxicology, 35(5), 435-441 (1997-01-01)
N,N-Diethyl-m-toluamide, an effective tick repellent, when applied to the skin, is the major component of essentially all of the products marketed for this purpose. It is used by about 30% of the US population, and by 23-29% of children in
P J Robbins et al.
Journal of toxicology and environmental health, 18(4), 503-525 (1986-01-01)
A review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET) is presented. Workers using repellent containing this compound may be exposed to greater than 442 g in 6 mo. In human studies, variable penetration into the skin
Pinky Kain et al.
Nature, 502(7472), 507-512 (2013-10-04)
There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the
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