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Sigma-Aldrich

1,3-Diamino-2-propanol

purum, ≥96.5% (GC)

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Synonym(s):
1,3-Diamino-2-hydroxypropane
Linear Formula:
NH2CH2CH(OH)CH2NH2
CAS Number:
616-29-5
Molecular Weight:
90.12
Beilstein:
741859
EC Number:
210-474-2
MDL number:
MFCD00008142
PubChem Substance ID:
329754481
NACRES:
NA.22

grade

purum

Quality Level

200

Assay

≥96.5% (GC)

form

solid

impurities

≤2.0% water

mp

40-44 °C (lit.)

solubility

water: soluble 1 g/10 mL

storage temp.

2-8°C

SMILES string

NCC(O)CN

InChI

1S/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2

InChI key

UYBWIEGTWASWSR-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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Application

1,3-Diamino-2-propanol was used in the synthesis of poly(2-hydroxypropylene imine), poly(2-hydroxypropylene imine ethylene imine) and poly(hydroxypropylene imine propylene imine). It was also used in the synthesis of tetranuclear mixed ligand copper(II) complex of a pyrazole containing Schiff base and a hydroxyhexahydropyrimidylpyrazole group.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Sachindranath Pal et al.
Inorganic chemistry, 44(11), 3880-3889 (2005-05-24)
A tetranuclear mixed ligand copper(II) complex of a pyrazole containing Schiff base and a hydroxyhexahydropyrimidylpyrazole and copper(II) and nickel(II) complexes of the Schiff base having N-donor atoms have been investigated. A 2 equiv amount of 5-methyl-3-formylpyrazole (MPA) and 2 equiv
Y W Hu et al.
Canadian journal of physiology and pharmacology, 60(12), 1493-1498 (1982-12-01)
The effect of diaminopropanol, an inhibitor of polyamine synthesis, on the metabolic response of liver to insulin was studied in streptozotocin-diabetic rats. Insulin elicited a prompt and very marked increase in ornithine and S-adenosylmethionine decarboxylase activities and in putrescine concentration.
L Alhonen-Hongisto
The Biochemical journal, 190(3), 747-754 (1980-09-15)
1. The mechanism of stimulation of S-adenosylmethionine decarboxylase (EC 4.1.1.50) activity by inhibitors of ornithine decarboxylase (EC 4.1.1.17), namely dl-alpha-difluoromethylornithine, 1,3-diaminopropane and 1,3-diaminopropan-2-ol, was studied in Ehrlich ascites-tumour cells grown in suspension cultures. 2. Difluoromethylornithine and diaminopropane, although decreasing the
W A Schulz et al.
Biological chemistry Hoppe-Seyler, 370(7), 729-736 (1989-07-01)
The relationship between polyamines and the rate of protein synthesis was investigated in non-proliferating cells: primary cultures of adult rat hepatocytes maintained in serum-free media, and treated with dexamethasone or dexamethasone + insulin. During the second day of culture, polyamine
H Raunio et al.
Biochemical pharmacology, 31(2), 189-193 (1982-01-15)
The induction of aryl hydrocarbon and ornithine decarboxylase by benz[a]-anthracene in the presence or absence of ornithine decarboxylase inhibitors was studied in three different cell culture systems. An almost complete abolishment of ornithine decarboxylase activity by 1,3-diamino-2-propanol or alpha-difluoremethyl ornithine
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