33270
L-2,3-Diaminopropionic acid hydrochloride
≥97.0%
Synonym(s):
3-Amino-L-alanine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C3H8N2O2 · HCl
CAS Number:
Molecular Weight:
140.57
PubChem Substance ID:
UNSPSC Code:
12352202
Beilstein/REAXYS Number:
4263944
MDL number:
SMILES string
O=C(O)[C@H](CN)N.Cl
InChI
1S/C3H8N2O2.ClH/c4-1-2(5)3(6)7;/h2H,1,4-5H2,(H,6,7);1H/t2-;/m0./s1
InChI key
SKWCZPYWFRTSDD-DKWTVANSSA-N
assay
≥97.0% (AT), ≥97.0%
form
solid
optical activity
[α]20/D +24±2°, c = 2% in 0.5 M HCl
loss
<1% loss on drying
mp
231-233 °C (dec.)
application(s)
peptide synthesis
Other Notes
Substrate for (Km =1mM), and competitive inhbitor (Ki =1mM, L-homoserine as substrate) of cystathionase from rat liver
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Rat liver L-diaminopropionate ammonia lyase. Identification as cystathionase.
I K Mushahwar et al.
The Journal of biological chemistry, 248(21), 7407-7411 (1973-11-10)
Joana R Viola et al.
Bioorganic & medicinal chemistry letters, 22(17), 5635-5638 (2012-08-04)
Here we report a novel class of peptides-d-diaminopropionic acids (Dap)-for gene delivery. These peptides have attractive properties for gene delivery, and the advantage that they can be easily manipulated in relation to their composition, abiding with tailored-design. We characterized the
Giovanni N Roviello et al.
Amino acids, 43(6), 2537-2543 (2012-06-13)
In this work, we report a synthetic approach to a Fmoc-protected nucleoamino acid, based on L-diaminopropanoic acid, carrying the DNA nucleobase on the alpha-amino group by means of an amide bond, suitable for the solid-phase synthesis of novel nucleopeptides of
Johnson Cheung et al.
Molecular microbiology, 74(3), 594-608 (2009-09-25)
Siderophores are iron-scavenging molecules produced by many microbes. In general, they are synthesized using either non-ribosomal peptide synthetase (NRPS) or NRPS-independent siderophore (NIS) pathways. Staphylococcus aureus produces siderophores, of which the structures of staphyloferrin A and staphyloferrin B are known.
J N Kalyani et al.
Journal of bacteriology, 194(20), 5604-5612 (2012-08-21)
Diaminopropionate ammonia lyase (DAPAL) is a pyridoxal-5'phosphate (PLP)-dependent enzyme that catalyzes the conversion of diaminopropionate (DAP) to pyruvate and ammonia and plays an important role in cell metabolism. We have investigated the role of the ygeX gene of Escherichia coli
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