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Merck
CN

33330

3,4-Diaminopyridine

purum, ≥99.0% (NT)

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About This Item

Empirical Formula (Hill Notation):
C5H7N3
CAS Number:
54-96-6
Molecular Weight:
109.13
EC Number:
200-220-9
UNSPSC Code:
12352100
PubChem Substance ID:
24860119
Beilstein/REAXYS Number:
110232
MDL number:
MFCD00006401

Key Documents

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grade

purum

assay

≥98.0% (TLC), ≥99.0% (NT)

mp

216-218 °C

solubility

water: soluble 0.5 g/10 mL, clear, slightly yellow (hot)

SMILES string

Nc1ccncc1N

InChI

1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)

InChI key

OYTKINVCDFNREN-UHFFFAOYSA-N

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General description

3,4-Diaminopyridine is a potassium (K+) channel-blocking agent. It is the most commonly used symptomatic treatment option for an autoimmune disorder, Lambert-Eaton myasthenic syndrome. It is the potential tool for the study of membrane ionic channels. It is known to improve fatigue and motor weakness in patients with multiple sclerosis.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Tyler B Tarr et al.
The Journal of physiology, 592(16), 3687-3696 (2014-07-13)
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder in which a significant fraction of the presynaptic P/Q-type Ca(2+) channels critical to the triggering of neurotransmitter release at the neuromuscular junction (NMJ) are thought to be removed. There is no cure
Jacqueline Palace et al.
Neuromuscular disorders : NMD, 22(2), 112-117 (2011-09-24)
Fast channel congenital myasthenic syndromes are rare, but frequently result in severe weakness. We report a case of 12 fast channel patients to highlight clinical features and management difficulties. Patients were diagnosed through genetic screening and identification of mutations shown
Tulio E Bertorini et al.
Journal of clinical neuromuscular disease, 12(3), 129-137 (2011-02-16)
To study the safety of 3-4 diaminopyridine (DAP) in patients with motor neuron diseases and to examine its efficacy in reducing muscle fatigue and weakness and in improving objective parameters of muscle function. Assessments of safety included a questionnaire of
G E Kirsch et al.
Biophysical journal, 22(3), 507-512 (1978-06-01)
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes. The apparent dissociation constants for this action are estimated to be 5.8 micron and 0.7 micron for external and internal applications, respectively
C Mainero et al.
Neurology, 62(11), 2044-2050 (2004-06-09)
3,4-diaminopyridine (3,4-DAP), a potassium (K+) channel blocker, improves fatigue and motor function in multiple sclerosis (MS). Although it was thought to do so by restoring conduction to demyelinated axons, recent experimental data show that aminopyridines administered at clinical doses potentiate
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