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Merck
CN

33366

Leptophos

PESTANAL®, analytical standard

Synonym(s):

O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate

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About This Item

Empirical Formula (Hill Notation):
C13H10BrCl2O2PS
CAS Number:
21609-90-5
Molecular Weight:
412.07
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754497
EC Number:
244-472-8
Beilstein/REAXYS Number:
2152663
MDL number:
MFCD00128037

Key Documents

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InChI key

CVRALZAYCYJELZ-UHFFFAOYSA-N

InChI

1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3

SMILES string

COP(=S)(Oc1cc(Cl)c(Br)cc1Cl)c2ccccc2

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, NMR: suitable, gas chromatography (GC): suitable

mp

71-73 °C

suitability

passes test for identity (NMR)

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

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General description

Leptophos, an organophosphorus insecticide found to be persistent in the environment, shows neurotoxic effects in humans. Its mode of action for pest control involves the inhibition of acetylcholinesterase enzyme activity.

Application

Leptophos may be used as an analytical reference standard for the quantification of the analyte in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector (SPME-GC-FPD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

flash_point_f

>212.0 °F

flash_point_c

> 100 °C

Regulatory Information

危险化学品
农药列管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCM1323
BCCJ4233
BCCC5203
BCBZ7738
BCBW5130

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Determination of organophosphorus pesticide residues in vegetables using solid phase micro-extraction coupled with gas chromatography-flame photometric detector.
Sapahin AH, et al.
Arabian Journal of Chemistry, 23(1), 636-641 (2014)
Photodegradation of leptophos.
Riskallah RM, et al.
Bulletin of Environmental Contamination and Toxicology, 23(1), 636-641 (1979)
Y Yamaguchi
Nihon eiseigaku zasshi. Japanese journal of hygiene, 43(6), 1159-1168 (1989-02-01)
In an attempt to carry out a pharmacokinetic study of the organophosphorous insecticide leptophos, which is known to produce delayed neurotoxicity (DNT), a practical method for the analysis of leptophos in tissue samples has been developed by utilizing high-performance liquid
[Effect of the organophosphorus compounds leptophos and TOCP on creatine kinase activity in hens].
K Katoh et al.
Nihon eiseigaku zasshi. Japanese journal of hygiene, 42(4), 847-857 (1987-10-01)
J E Chambers et al.
Journal of biochemical toxicology, 4(3), 201-203 (1989-01-01)
The oxidative desulfuration of the three phosphorothionate insecticides--chlorpyrifos, chlorpyrifos-methyl, and leptophos--was studied in rat brain and liver. Hepatic microsomes demonstrated activities of 4-28 nmol/g/min, with male activity 2- to 4-fold higher than female activity. Very low desulfuration activity of all
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