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Merck
CN

33437

Ninhydrin

puriss. p.a., ≥99%

Synonym(s):

1,2,3-Indantrione monohydrate, 2,2-Dihydroxy-1,3-indanedione, Trioxohydrindene monohydrate

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About This Item

Empirical Formula (Hill Notation):
C9H6O4
CAS Number:
485-47-2
Molecular Weight:
178.14
EC Number:
207-618-1
UNSPSC Code:
12352100
PubChem Substance ID:
329754547
Beilstein/REAXYS Number:
1910963
MDL number:
MFCD00003791

Key Documents

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InChI key

FEMOMIGRRWSMCU-UHFFFAOYSA-N

InChI

1S/C9H6O4/c10-7-5-3-1-2-4-6(5)8(11)9(7,12)13/h1-4,12-13H

SMILES string

OC1(O)C(=O)c2ccccc2C1=O

grade

puriss. p.a.

assay

≥99%

ign. residue

≤0.1% (as SO4)

pH

4.6-5.0 (20 °C, 1%)

mp

250 °C (dec.) (lit.)

storage temp.

2-8°C

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Application

Ninhydrin (triketohydrindene hydrate) may be used as reagent for the quantification of amino acids and peptides by photometric method and colorimetric method. It may be used to prepare the ninhydrin reagent, by mixing ninhydrin and hydrindantin (reduced form of ninhydrin) in dimethyl sulfoxide. This reagent is used in manual ninhydrin method for the quantitative determination of amino acids.
Used for the detection of free amino groups in amino acids, peptides and proteins.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBS0473V
SZBG0060V
SZBG0060
SZBF2100V

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Photometric ninhydrin method for use in the chromatography of amino acids.
S MOORE et al.
The Journal of biological chemistry, 176(1), 367-388 (1948-10-01)
The determination of amino-acids with ninhydrin.
Yemm EW, et al.
Analyst, 80(948), 209-214 (1955)
Jianhui Gu et al.
Journal of tissue engineering and regenerative medicine, 6(2), 163-168 (2011-03-04)
This paper describes a clinical case study in which a chitosan/polyglycolic acid nerve guidance conduit (chitosan-PGA NGC) was utilized to repair a 30 mm long median nerve defect in the right distal forearm of a 55 year-old male patient. Thirty-six
Chao Li et al.
Journal of biomaterials science. Polymer edition, 23(1-4), 405-424 (2011-02-12)
Biomaterials have been playing important roles in cartilage regeneration. Although many scaffolds have been reported to enhance cartilage regeneration, none of the scaffolds available are optimal regarding mechanical properties, integration with host cartilage and providing proper micro-environment for chondrocyte attachment
Joseph Almog et al.
Journal of forensic sciences, 56 Suppl 1, S162-S165 (2011-01-14)
We explored the quality distribution of ninhydrin-developed prints on A4 bond paper in two groups of individuals, in Israel and in India. While the quality distributions of the developed marks in both countries had some dissimilarities, both groups showed the
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