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33709

Tetrahydrofuran

Name: Tetrahydrofuran
Brand: SIAL

≥99.9% (GC), contains ~250 mg/L 2, 6-di-tert.-butyl-4-methylphenol as stabilizer, puriss. p.a.

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Linear Formula:

(CH₂)₃CH₂O

CAS Number:

109-99-9

Molecular Weight:

72.11

UNSPSC Code:

12352005

PubChem Substance ID:

57648904

EC Number:

203-726-8

Beilstein/REAXYS Number:

102391

MDL number:

MFCD00005356

Assay:

≥99.9% (GC)

Technique(s):

GC/GC: suitable

Bp:

65-67 °C (lit.)

Vapor pressure:

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

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Properties

Product Name

Tetrahydrofuran, puriss. p.a., ≥99.9% (GC)

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.9% (GC)

form

liquid

autoignition temp.

610 °F

contains

~250 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

GC/GC: suitable

impurities

≤0.001% free acid (as CH₃COOH), ≤0.001% non-volatile matter, ≤0.005% peroxides (as H₂O₂), ≤0.05% water (Karl Fischer)

color

APHA: <20

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H₂O: soluble

density

0.889 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg, B: ≤0.02 mg/kg, Ba: ≤0.1 mg/kg, Ca: ≤0.5 mg/kg, Cd: ≤0.05 mg/kg, Co: ≤0.02 mg/kg, Cr: ≤0.02 mg/kg, Cu: ≤0.02 mg/kg, Fe: ≤0.1 mg/kg, Mg: ≤0.1 mg/kg, Mn: ≤0.02 mg/kg, Ni: ≤0.02 mg/kg, Pb: ≤0.1 mg/kg, Sn: ≤0.1 mg/kg, Zn: ≤0.1 mg/kg

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. The crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Application

Tetrahydrofuran has been used for the dissolution of poly-ε-caprolactone (PCL), during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds. It has been used for the dissolution of 1,3-diaminopentane, during the synthesis of acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)-1,3-diaminopentane (117) polymer.

Packaging

bottled under inert gas

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran

Go to our Greener Alternative-Cyclopentyl methylether

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

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signalword

Danger

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Regulatory Information

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Tissue-specific gene delivery via nanoparticle coating.

Todd J Harris et al.

Biomaterials, 31(5), 998-1006 (2009-10-24)

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and

Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.

Mak TCW, et al.

J. Chem. Phys. , 42(8), 2732-2737 (1965)

Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.

Boivin TLB.

Tetrahedron, 43(15), 3309-3362 (1987)

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