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Merck
CN

33709

Tetrahydrofuran

≥99.9% (GC), contains ~250 mg/L 2, 6-di-tert.-butyl-4-methylphenol as stabilizer, puriss. p.a.

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
UNSPSC Code:
12352005
PubChem Substance ID:
EC Number:
203-726-8
Beilstein/REAXYS Number:
102391
MDL number:
Assay:
≥99.9% (GC)
Technique(s):
GC/GC: suitable
Vapor pressure:
114 mmHg ( 15 °C), 143 mmHg ( 20 °C)
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Product Name

Tetrahydrofuran, puriss. p.a., ≥99.9% (GC)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.9% (GC)

form

liquid

autoignition temp.

610 °F

contains

~250 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

GC/GC: suitable

impurities

≤0.001% free acid (as CH3COOH), ≤0.001% non-volatile matter, ≤0.005% peroxides (as H2O2), ≤0.05% water (Karl Fischer)

color

APHA: <20

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg, B: ≤0.02 mg/kg, Ba: ≤0.1 mg/kg, Ca: ≤0.5 mg/kg, Cd: ≤0.05 mg/kg, Co: ≤0.02 mg/kg, Cr: ≤0.02 mg/kg, Cu: ≤0.02 mg/kg, Fe: ≤0.1 mg/kg, Mg: ≤0.1 mg/kg, Mn: ≤0.02 mg/kg, Ni: ≤0.02 mg/kg, Pb: ≤0.1 mg/kg, Sn: ≤0.1 mg/kg, Zn: ≤0.1 mg/kg

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General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. The crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Application

Tetrahydrofuran has been used for the dissolution of poly-ε-caprolactone (PCL), during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds. It has been used for the dissolution of 1,3-diaminopentane, during the synthesis of acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)-1,3-diaminopentane (117) polymer.

Packaging

bottled under inert gas

Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Todd J Harris et al.
Biomaterials, 31(5), 998-1006 (2009-10-24)
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and
Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.
Mak TCW, et al.
J. Chem. Phys. , 42(8), 2732-2737 (1965)
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
Boivin TLB.
Tetrahedron, 43(15), 3309-3362 (1987)
Haiying Yu et al.
Biomaterials, 30(4), 508-517 (2008-11-01)
Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network that temporally precedes new bone formation, and spatially originates
C N Ong et al.
British journal of industrial medicine, 48(9), 616-621 (1991-09-01)
Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Head space gas chromatography (GC) with an FID detector was used for determination of

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