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Merck
CN

33731

Trichloroacetic acid

puriss. p.a., ACS reagent, ≥99.5%

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
76-03-9
Molecular Weight:
163.39
EC Number:
200-927-2
UNSPSC Code:
12352100
PubChem Substance ID:
57648907
Beilstein/REAXYS Number:
970119
MDL number:
MFCD00004177

Key Documents

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InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(=O)C(Cl)(Cl)Cl

grade

ACS reagent, puriss. p.a.

assay

≥99.5%

impurities

≤0.002% heavy metals (as Pb), ≤0.005% water insolubles

ign. residue

≤0.01% (as SO4)

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg, nitrate (NO3-): ≤20 mg/kg, phosphate (PO43-): ≤5 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

Cu: ≤5 mg/kg, Fe: ≤10 mg/kg

suitability

complies for appearance of solution

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General description

Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolite of trichloroethylene (TCE).

Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.
Trichloroacetic acid may be used for the quantification of inorganic phosphorus in various biological samples (serum, urine and stool ash solutions). It may be used for the elimination of acid-soluble and lipid phosphorous during the quantitative estimation of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues. 10% trichloroacetic acid may be employed for the preparation of radioactive proteins.

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H314,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SZBG1450
SZBG1040
SZBG0700
SZBG014A
SZBG0140

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A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.
G SCHMIDT et al.
The Journal of biological chemistry, 161, 83-89 (1945-01-01)
Solubility of albumin in alcohol after precipitation by trichloroacetic acid: a simplified procedure for separation of albumin.
J R DEBRO et al.
Nature, 178(4541), 1067-1067 (1956-11-10)
A microcolorimetric method for the determination of inorganic phosphorus.
H H TAUSSKY et al.
The Journal of biological chemistry, 202(2), 675-685 (1953-06-01)
S L Herren-Freund et al.
Toxicology and applied pharmacology, 90(2), 183-189 (1987-09-15)
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic
Ying Wang et al.
Diabetes, 63(8), 2643-2655 (2014-03-13)
After diabetes, the heart has a singular reliance on fatty acid (FA) for energy production, which is achieved by increased coronary lipoprotein lipase (LPL) that breaks down circulating triglycerides. Coronary LPL originates from cardiomyocytes, and to translocate to the vascular
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