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Methyldibromoglutaronitrile

analytical standard

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Synonym(s):
1,2-Dibromo-2,4-dicyanobutane, 1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile, 2-Bromo-2-(bromomethyl)glutaronitrile
Empirical Formula (Hill Notation):
C6H6Br2N2
CAS Number:
35691-65-7
Molecular Weight:
265.93
EC Number:
252-681-0
MDL number:
MFCD00072483
PubChem Substance ID:
329754978
NACRES:
NA.24

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

51-55 °C

application(s)

environmental

format

neat

storage temp.

2-8°C

SMILES string

BrCC(Br)(CCC#N)C#N

InChI

1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2

InChI key

DHVLDKHFGIVEIP-UHFFFAOYSA-N

Related Categories

General description

Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.

Application

Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302 - H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

农药列管产品

Certificates of Analysis (COA)

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Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection: Method validation
Rastogi CS, et al.
Journal of Chromatography A, 1031(1-2), 315-317 (2004)
A C De Groot et al.
Journal of the American Academy of Dermatology, 35(5 Pt 1), 743-747 (1996-11-01)
Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4
Patch testing with methyldibromoglutaronitrile
Geier J, et al.
American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 11, 207-212 (2000)
Axel Schnuch et al.
Contact dermatitis, 56(6), 331-337 (2007-06-20)
Although genetic factors probably account for differences in susceptibility to contact allergy, they have not yet been identified, partly due to an insufficient understanding of 'susceptibility'. Regarding polysensitization (PS) as a sign of increased susceptibility, we studied the relationship between
Jakob Torp Madsen et al.
Contact dermatitis, 63(4), 209-214 (2010-08-25)
Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase
View All Related Papers

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