34392
Methyldibromoglutaronitrile
analytical standard
Synonym(s):
1,2-Dibromo-2,4-dicyanobutane, 1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile, 2-Bromo-2-(bromomethyl)glutaronitrile
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About This Item
Empirical Formula (Hill Notation):
C6H6Br2N2
CAS Number:
Molecular Weight:
265.93
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
EC Number:
252-681-0
MDL number:
grade
analytical standard
Quality Level
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
51-55 °C
application(s)
environmental
format
neat
storage temp.
2-8°C
SMILES string
BrCC(Br)(CCC#N)C#N
InChI
1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2
InChI key
DHVLDKHFGIVEIP-UHFFFAOYSA-N
General description
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.
Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Application
Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
农药列管产品
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Manuela Pellegrini et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 1112-1116 (2011-08-30)
A simple and rapid gas chromatography (GC) method with mass spectrometry (MS) detection has been developed for the determination of methyldibromo glutaronitrile (MDBGN) in cosmetic products. The presence of this preservative in commercial cosmetic samples is prohibited since 2007 because
Annice Heratizadeh et al.
Contact dermatitis, 62(6), 330-337 (2010-06-19)
While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. The objective of this study was to find a
Jakob Torp Madsen et al.
Contact dermatitis, 63(4), 209-214 (2010-08-25)
Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 34392-500MG | 04061826758472 |