35847
2′,7′-Dichlorofluorescin diacetate
≥90% (HPLC)
Synonym(s):
2′,7′-Dichlorodihydrofluorescein diacetate
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About This Item
Empirical Formula (Hill Notation):
C24H16Cl2O7
CAS Number:
Molecular Weight:
487.29
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
4610273
MDL number:
SMILES string
CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C(c2cc1Cl)c4ccccc4C(O)=O
InChI
1S/C24H16Cl2O7/c1-11(27)31-21-9-19-15(7-17(21)25)23(13-5-3-4-6-14(13)24(29)30)16-8-18(26)22(32-12(2)28)10-20(16)33-19/h3-10,23H,1-2H3,(H,29,30)
InChI key
PXEZTIWVRVSYOK-UHFFFAOYSA-N
assay
≥90% (HPLC)
mp
209-210 °C (lit.)
solubility
DMF: soluble, DMSO: soluble
fluorescence
λex 504 nm; λem 529 nm in 0.1 M Tris pH 8.0, esterase; H2O2
suitability
suitable for fluorescence
storage temp.
−20°C
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Cell-permeable fluorogenic probe used to measure reactive oxygen species (ROS) within cells by detection of enzymatically formed hydrogen peroxide
Regulatory Information
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A Sanchez Ferrer et al.
Analytical biochemistry, 187(1), 129-132 (1990-05-15)
A sensitive enzymatic assay for oxidase reactions both in aqueous solution and in hexadecyltrimethylammoniumbromide (CTAB) reversed micelles has been developed. The assay is based on the fluorescence detection of dichlorofluorescein, which is formed by hydrogen peroxide oxidation of the nonfluorescent
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Cell biology international, 24(10), 757-760 (2000-10-12)
Intracellular 2,7-dichlorofluorescin (H(2)DCF) oxidation is often used to measure the production of reactive oxygen species (ROS) within cells. The rate of H(2)DCF oxidation depends on the concentration of glutathione, which is an alternative target for ROS. Our results suggest that
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