36777
2′,3′-Dideoxyinosine
≥95% (HPLC)
Synonym(s):
ddI, ddIno
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About This Item
Empirical Formula (Hill Notation):
C10H12N4O3
CAS Number:
Molecular Weight:
236.23
UNSPSC Code:
12161700
Beilstein/REAXYS Number:
3619529
MDL number:
assay
≥95% (HPLC)
impurities
≤1% water
mp
193-195 °C
application(s)
agriculture
environmental
storage temp.
2-8°C
SMILES string
OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChI key
BXZVVICBKDXVGW-NKWVEPMBSA-N
Other Notes
Experimental anti-retroviral agent
Regulatory Information
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Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
G Ahluwalia et al.
Biochemical pharmacology, 36(22), 3797-3800 (1987-11-15)
J E Dahlberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(8), 2469-2473 (1987-04-01)
Certain dideoxynucleosides have been shown to markedly inhibit the infectivity of human T-lymphotropic virus type III/lymphadenopathy-associated virus, the causative agent of acquired immunodeficiency syndrome (AIDS). Our present studies demonstrate that these drugs are broad spectrum antiretroviral agents capable of inhibiting
Nicolas Sluis-Cremer et al.
Antimicrobial agents and chemotherapy, 53(9), 3715-3719 (2009-07-15)
Although the approved nucleoside reverse transcriptase (RT) inhibitors (NRTI) are integral components of therapy for human immunodeficiency virus type 1 (HIV-1) infection, they can have significant limitations, including the selection of NRTI-resistant HIV-1 and cellular toxicity. Accordingly, there is a
H Mitsuya et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(6), 1911-1915 (1986-03-01)
Human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV) is a a newly discovered lymphotropic retrovirus that is cytopathic for helper/inducer T cells in vitro. This virus is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 850715P-500MG | 04061835231188 |
| 850715P-25MG | 04061835231171 |
| 850715P-1G | 04061835231157 |
| 850715P-200MG | 04061835231164 |
| P3531-100MG | 04061834368106 |
| P3531-500MG | 04061834368113 |
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