37296
Dihydrofolic acid
≥88% (enzymatic)
Synonym(s):
7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C19H21N7O6
CAS Number:
Molecular Weight:
443.41
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
69017
MDL number:
InChI key
OZRNSSUDZOLUSN-LBPRGKRZSA-N
SMILES string
NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
InChI
1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
assay
≥88% (enzymatic)
impurities
≤12% water
solubility
0.1 M NaOH: 10 mg/mL, slightly hazy, orange
General description
Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.
Other Notes
Assay of dihydrofolate reductase
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Dihydrofolate reductase: a coupled radiometric assay.
P Reyes et al.
Methods in enzymology, 122, 360-367 (1986-01-01)
Samuel Thompson et al.
eLife, 9 (2020-07-24)
Protein mutational landscapes are shaped by the cellular environment, but key factors and their quantitative effects are often unknown. Here we show that Lon, a quality control protease naturally absent in common E. coli expression strains, drastically reshapes the mutational
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service