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Merck
CN

37906

Supelco

Methacycline hydrochloride

VETRANAL®, analytical standard

Synonym(s):

6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H22N2O8 · HCl
CAS Number:
3963-95-9
Molecular Weight:
478.88
Beilstein:
5470951
EC Number:
223-568-3
MDL number:
MFCD04972012
UNSPSC Code:
41116107
PubChem Substance ID:
329755720

Key Documents

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grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

SMILES string

Cl[H].[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H22N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31);1H/t10-,14-,15+,17+,22+;/m1./s1

InChI key

VZQARNDJLLWXGL-CCHMMTNSSA-N

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General description

Chemical structure: tetracycline

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ0890

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Product 37906, Methacycline? 

    Product 37906, Methacycline, is soluble in water.  It is sparingly soluble in alcohol.  It is also practically insoluble in ether and chloroform.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

W Naidong et al.
Journal of chromatography, 586(1), 61-66 (1991-11-08)
Isocratic column liquid chromatography on poly(styrene-divinylbenzene) copolymer allowed complete separation of metacycline, 4-epimetacycline, oxytetracycline, doxycycline and 6-epidoxycycline. 2-Acetyl-2-decarboxamidometacycline was eluted on the tail of metacycline. The mobile phase was 2-methyl-2-propanol-0.2 M phosphate buffer (pH 9.0)-0.01 M sodium ethylenediaminetetraacetate (pH 9.0)-water
C E Tsai et al.
Research in veterinary science, 56(3), 277-283 (1994-05-01)
A new continuous separation method was developed for the determination of five different tetracyclines (oxytetracycline, tetracycline, chlortetracycline, methacycline and doxycycline). A bioassay using minimum medium (MM) seeded with Bacillus subtilis ATCC 6633 was carried out for the detection, with simple
M C Mahedero et al.
Journal of pharmaceutical and biomedical analysis, 37(5), 1101-1104 (2005-05-03)
Demeclocycline (DM) and methacycline (MT) have been determined by europium-sensitized fluorescence, using EDTA as co-ligand and cetyltrimethylammonium chloride as surfactant. The methods have been developed in slightly alkaline solutions, with the formation of a new chelate where the lanthanide ion
Jiantao Li et al.
Talanta, 75(5), 1245-1252 (2008-07-01)
An automated system using on-line solid-phase extraction (SPE) high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the determination of tetracyclines (TCs), such as tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), metacycline (MC), and doxycycline (DC) in honey. One
Andrea Nastri Grasso et al.
Journal of fluorescence, 19(4), 715-721 (2009-02-03)
Tetracycline possesses a great tendency to form complexes with a number of chemical species, particularly with Eu3+ ions. In this work we investigate the europium optical properties of three tetracyclines europium complexes: Metacycline (MTc), Oxytetracycline (OTc), and Chlortetracycline (CTc), in
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