38171
6-Mercaptopurine
analytical standard
Synonym(s):
6-Purinethiol, 6-Thiohypoxanthine
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About This Item
Empirical Formula (Hill Notation):
C5H4N4S
CAS Number:
Molecular Weight:
152.18
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
200-037-4
MDL number:
grade
analytical standard
Quality Level
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
storage condition
under inert gas (argon)
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤20% water
application(s)
pharmaceutical
format
neat
SMILES string
S=C1NC=NC2=C1NC=N2
InChI
1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChI key
GLVAUDGFNGKCSF-UHFFFAOYSA-N
Gene Information
human ... PPAT(5471)
General description
6-Mercaptopurine (6-MP) is a purine analog, frequently prescribed for treating childhood acute lymphoblastic leukemia. It is also extensively used in the treatment of corticosteroid dependent inflammatory bowel disease (IBD) or the Crohn′s disease.
Application
6-Mercaptopurine (6-MP) may be used as an analytical reference standard for the determination of the analyte in biological samples by high-performance liquid chromatography (HPLC) technique.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 2 - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity.
Cuffari C, et al.
Gut, 39(3), 401-406 (1996)
Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells
Hawwa AF, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 401-409 (2009)
Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia.
Lennard L, et al.
British Journal of Clinical Pharmacology, 16(4), 359-363 (1983)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 38171-25MG | 04061834390466 |