Skip to Content
Merck
CN

38171

Supelco

6-Mercaptopurine

analytical standard

Synonym(s):

6-Purinethiol, 6-Thiohypoxanthine

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C5H4N4S
CAS Number:
50-44-2
Molecular Weight:
152.18
EC Number:
200-037-4
MDL number:
MFCD00599524
UNSPSC Code:
12352200
PubChem Substance ID:
329755748

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

analytical standard

Quality Level

100

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

storage condition

under inert gas (argon)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤20% water

application(s)

pharmaceutical

format

neat

SMILES string

S=C1NC=NC2=C1NC=N2

InChI

1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

GLVAUDGFNGKCSF-UHFFFAOYSA-N

Gene Information

human ... PPAT(5471)

General description

6-Mercaptopurine (6-MP) is a purine analog, frequently prescribed for treating childhood acute lymphoblastic leukemia. It is also extensively used in the treatment of corticosteroid dependent inflammatory bowel disease (IBD) or the Crohn′s disease.

Application

6-Mercaptopurine (6-MP) may be used as an analytical reference standard for the determination of the analyte in biological samples by high-performance liquid chromatography (HPLC) technique.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H341,H361fd

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCF2866
BCCB4485
BCCB1613
BCBZ4889
BCBW8626

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography
Ding TL and Benet LZ
Journal of Chromatography. B, Biomedical Sciences and Applications, 163(3), 281-288 (1979)
6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity.
Cuffari C, et al.
Gut, 39(3), 401-406 (1996)
Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells
Hawwa AF, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 401-409 (2009)
Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia.
Lennard L, et al.
British Journal of Clinical Pharmacology, 16(4), 359-363 (1983)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service