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Merck
CN

41244

N-Desmethyl ofloxacin

analytical standard

Synonym(s):

9-Fluoro-2,3-dihydro-3-methyl-10-(1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C17H18FN3O4
CAS Number:
82419-52-1
Molecular Weight:
347.34
NACRES:
NA.24
PubChem Substance ID:
329756078
UNSPSC Code:
12352200
MDL number:
MFCD00871868
Beilstein/REAXYS Number:
4890029

Key Documents

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InChI key

WKRSSAPQZDHYRV-UHFFFAOYSA-N

InChI

1S/C17H18FN3O4/c1-9-8-25-16-13-10(15(22)11(17(23)24)7-21(9)13)6-12(18)14(16)20-4-2-19-3-5-20/h6-7,9,19H,2-5,8H2,1H3,(H,23,24)

grade

analytical standard

assay

≥96.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

mp

256-262 °C

application(s)

clinical testing

format

neat

Quality Level

100

General description

N-Desmethyl ofloxacin is one of the active metabolites of ofloxacin, a drug prescribed for treating bacterial infections (effective against both Gram-positive and Gram-negative bacteria) that acts by inhibiting the enzyme DNA gyrase.

Application

N-Desmethyl ofloxacin may be used as an analytical reference standard for the determination of the analyte in biological samples by high-pressure liquid chromatography with fluorescence detection and capillary electrophoresis using laser-induced fluorescence detection technique.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBX0178
BCBS0669V
BCBS0669
BCBR7984

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Stereoselective determination of ofloxacin and its metabolites in human urine by capillary electrophoresis using laser-induced fluorescence detection
Horstkotter C and Blaschke G
Journal of Chromatography. B, Biomedical Sciences and Applications, 754(1), 169-178 (2001)
Kinetics of ofloxacin and its metabolites in cerebrospinal fluid after a single intravenous infusion of 400 milligrams of ofloxacin.
Nau R, et al.
Antimicrobial Agents and Chemotherapy, 38(8), 1849-1853 (1994)

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