424455
Resorufin
Dye content 95 %
Synonym(s):
7-Hydroxy-3H-phenoxazin-3-one, NSC 12097
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About This Item
Empirical Formula (Hill Notation):
C12H7NO3
CAS Number:
Molecular Weight:
213.19
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
211-241-8
Beilstein/REAXYS Number:
174850
MDL number:
InChI key
HSSLDCABUXLXKM-UHFFFAOYSA-N
InChI
1S/C12H7NO3/c14-7-1-3-9-11(5-7)16-12-6-8(15)2-4-10(12)13-9/h1-6,14H
SMILES string
O=C(C=C1)C=C2C1=NC3=CC=C(O)C=C3O2
form
powder
composition
Dye content, 95%
mp
>300 °C (lit.)
λmax
573 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
General description
Resorufin, a redox probe can be used to visualize cell respiration directly. It is highly fluorescent and has an excitation maximum at 563nm and emission maximum at 587nm.
Application
Resorufin has been used in the measurements of hydrogen peroxide generation.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Yutaka Hitomi et al.
Analytical chemistry, 83(24), 9213-9216 (2011-11-18)
We developed a metal-based fluorescent probe for H(2)O(2) called MBFh1, which has an iron complex as a reaction site for H(2)O(2) and a 3,7-dihydroxyphenoxazine derivative as the fluorescent reporter unit. The iron complex reacts quickly with H(2)O(2) to form oxidants
Karsten Klopffleisch et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 8), 883-892 (2012-08-08)
A low-resolution structure of the catalytic subunit CK2α of human protein kinase CK2 (formerly known as casein kinase 2) in complex with the ATP-competitive inhibitor resorufin is presented. The structure supplements previous human CK2α structures in which the interdomain hinge/helix
Ahmed A El-Sherbeni et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1498-1507 (2014-06-28)
Cytochrome P450 (P450) enzymes mediate arachidonic acid (AA) oxidation to several biologically active metabolites. Our aims in this study were to characterize AA metabolism by different recombinant rat P450 enzymes and to identify new targets for modulating P450-AA metabolism in
Hubert M Piwonski et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(22), E1437-E1443 (2012-05-09)
Enzymatic inhibition by product molecules is an important and widespread phenomenon. We describe an approach to study product inhibition at the single-molecule level. Individual HRP molecules are trapped within surface-tethered lipid vesicles, and their reaction with a fluorogenic substrate is
Eyal Golub et al.
The Analyst, 136(21), 4397-4401 (2011-09-02)
Hemin/G-quadruplex catalyzes the H(2)O(2)-mediated oxidation of Amplex Red to the fluorescent product resorufin. This process is implemented to develop hairpin nucleic acid structures for the detection of DNA, to probe the catalytic activity of glucose oxidase, to use the thrombin-aptamer
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