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Merck
CN

43698

1,2-Distearoyl-sn-glycero-3-phosphocholine

≥99.0% (TLC)

Synonym(s):

PC, 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1,2-distearoyl, L-α-Phosphatidylcholine, distearoyl, L-β,γ-Distearoyl-α-lecithin, DSPC, PC(18:0/18:0)

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About This Item

Empirical Formula (Hill Notation):
C44H88NO8P
CAS Number:
816-94-4
Molecular Weight:
790.15
UNSPSC Code:
12352211
Beilstein/REAXYS Number:
3923978
MDL number:
MFCD00036905

Key Documents

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assay

≥99.0% (TLC)

shipped in

wet ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

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General description

Well-defined liposomes, loaded with a molecule of choice, are formed by a single hydration step.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Peter J Kueffer et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6512-6517 (2013-03-29)
The application of boron neutron capture therapy (BNCT) following liposomal delivery of a (10)B-enriched polyhedral borane and a carborane against mouse mammary adenocarcinoma solid tumors was investigated. Unilamellar liposomes with a mean diameter of 134 nm or less, composed of
Pan Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 349-354 (2012-07-18)
Ultrasound targeted microbubble destruction (UTMD) was one of the most promising strategies to enhance drug delivery in cancer therapy. Microbubbles (MBs) serve as a vehicle to carry anti-tumor drugs and locally release them when exposed to therapeutic ultrasound, resulting in
Antonella Accardo et al.
International journal of nanomedicine, 7, 2007-2017 (2012-05-24)
Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This study addresses novel liposome composition approaches to specifically target tissues overexpressing bombesin (BN)
Sweta Modi et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 330-339 (2012-07-18)
Nanoparticulate drug carriers such as liposomal drug delivery systems are of considerable interest in cancer therapy because of their ability to passively accumulate in solid tumors. For liposomes to have practical utility for antitumor therapy in patients, however, optimization of
Hyo-Kyung Han et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 500-507 (2012-04-24)
This study aimed to design the chitosan coated liposomes of alendronate and optimize their in vitro/in vivo characteristics to improve the bioavailability as well as potentially to reduce the mucosal irritation of alendronate. Liposomes of alendronate were prepared with DSPC/DSPG
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