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Merck
CN

43796

1,4-Dithioerythritol

≥99.0% (RT)

Synonym(s):

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

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About This Item

Linear Formula:
HSCH2CH(OH)CH(OH)CH2SH
CAS Number:
Molecular Weight:
154.25
EC Number:
229-998-8
UNSPSC Code:
12352201
PubChem Substance ID:
Beilstein/REAXYS Number:
1719756
MDL number:
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assay

≥99.0% (RT)

mp

82-84 °C (lit.), 82-85 °C

solubility

H2O: 10 mg/mL, clear, colorless

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤500 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

storage temp.

2-8°C

SMILES string

O[C@@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

InChI key

VHJLVAABSRFDPM-ZXZARUISSA-N

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.


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pictograms

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hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Yang-Rae Kim et al.
ACS applied materials & interfaces, 2(1), 292-295 (2010-04-02)
A strategy for the rational design of a novel colorimetric sensor based on dithioerythritol-modified gold nanoparticles for the selective recognition of Hg2+ in aqueous media is presented. This approach relies on the combination of gold nanoparticles with Hg2+ through sulfur-Hg2+-sulfur
Annamaria Tonazzi et al.
Chemico-biological interactions, 203(2), 423-429 (2013-02-14)
H(2)O(2) inhibits the [(3)H]carnitine/carnitine antiport catalysed by the mitochondrial carnitine/acylcarnitine transporter reconstituted in proteoliposomes. The inhibition was reversed by dithioerythritol, N-acetylcysteine and L-cysteine. Inhibition time-dependence revealed a faster and a slower reaction stages with orders of reaction of 1.0 and
András Kolozsi et al.
Inorganic chemistry, 47(9), 3832-3840 (2008-04-03)
The aqueous solutions of arsenous acid with the meso and racemic forms of 1,4-dithiol-butane-2,3-diol, namely, dithioerythritol (dte) and dithiothreitol (dtt), respectively, were titrated pH-metrically in different molar ratios. The p K a values determined for As(OH) 3, and dtt were