43975
Ethylmalonic acid
analytical standard
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About This Item
Linear Formula:
C2H5CH(COOH)2
CAS Number:
Molecular Weight:
132.11
EC Number:
210-007-2
UNSPSC Code:
41116107
MDL number:
Beilstein/REAXYS Number:
774334
InChI key
UKFXDFUAPNAMPJ-UHFFFAOYSA-N
InChI
1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9)
SMILES string
CCC(C(O)=O)C(O)=O
grade
analytical standard
assay
≥98.0% (GC)
shelf life
limited shelf life, expiry date on the label
mp
112-114 °C (lit.)
application(s)
clinical testing
format
neat
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General description
Ethylmalonic acid (EMA) is a branched fatty acid. It is a urinary organic acid, used as an important biochemical indicator of abnormal metabolism created by various diseases.
Application
Ethylmalonic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
It may be used as an analytical standard to investigate its role in the inhibition of succinate and malate transport through the mitochondrial membranes in rats.
- Human biological fluids using liquid chromatography coupled to mass spectrometry (LC-MS).
- Urine samples of uterine myoma and uterine cervical cancer patients using gas chromatography and gas chromatography–mass spectrometry.
It may be used as an analytical standard to investigate its role in the inhibition of succinate and malate transport through the mitochondrial membranes in rats.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Liquid chromatographic?mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria
Sriboonvorkul N, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 941, 116-122 (2013)
Gas chromatographic profiling and pattern recognition analysis of urinary organic acids from uterine myoma patients and cervical cancer patients
Kim R-K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 712(1-2), 11-22 (1998)
Alexandre Umpierrez Amaral et al.
Molecular genetics and metabolism, 105(1), 84-90 (2011-12-03)
Tissue accumulation and high urinary excretion of ethylmalonic acid (EMA) occur in ethylmalonic encephalopathy (EE) and short chain acyl-CoA dehydrogenase deficiency (SCADD). Although these autosomal recessive disorders are clinically characterized by neurological abnormalities, the mechanisms underlying the brain damage are
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