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Merck
CN

44508

Heroin hydrochloride solution

~1 mg/mL in acetonitrile, analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C21H23NO5 · HCl
CAS Number:
1502-95-0
Molecular Weight:
405.87
UNSPSC Code:
41116107
MDL number:
MFCD00190605

Key Documents

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InChI key

FZJYQGFGNHGSFX-PVQKIFDLSA-N

InChI

1S/C21H23NO5.ClH/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20;/h4-7,14-15,17,20H,8-10H2,1-3H3;1H/t14-,15+,17-,20-,21-;/m0./s1

SMILES string

Cl.CN1CC[C@]23[C@H]4Oc5c(OC(C)=O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)c35

assay

≥98.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

drug control

USDEA Schedule I; Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada

concentration

~1 mg/mL in acetonitrile

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

Packaging

ampoule contains 1.2mL solution

Regulatory Information

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I Demaret et al.
Revue medicale de Liege, 68(5-6), 287-293 (2013-07-31)
Heroin (or diacetylmorphine), a depressant nervous central system, is a semi-synthetic opiate. Its main adverse effect, respiratory depression, can lead to death, especially after an intravenous injection. By loss of tolerance, an overdose can be lethal following heroin use after
Marc Walter et al.
Journal of clinical psychopharmacology, 33(2), 193-198 (2013-02-21)
Heroin dependence is associated with a stressful environment and with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. The present study examined the acute effects of intravenous heroin versus placebo on the HPA axis response in heroin-dependent patients. Twenty-eight heroin-dependent patients in
Hannah Skuse et al.
Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association, 20(9), 14-19 (2013-03-23)
This article discusses the administration of intranasal diamorphine as an analgesia-in paediatric trauma care. The authors outline evidence for its use and discuss a recent multicentre safety study of an intranasal diamorphine product. In addition, they advise emergency department nurses
Ruixue Yin et al.
International journal of medical sciences, 10(3), 299-306 (2013-02-21)
To investigate whether microvascular damage is involved in the pathogenesis of heroin induced spongiform leukoencephalopathy (HSLE). The brain tissues were collected from 4 HSLE patients and 5 controls and then fixed in 4% paraformaldehyde. The frontal lobe, corpus callosum and
D Adam Algren et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 9(1), 106-115 (2013-01-30)
During the summer of 2005, multiple cities in the United States began to report outbreaks of fentanyl-associated fatalities among illicit drug users. The objectives of this study were to (1) determine if an outbreak of fentanyl-associated fatalities occurred in mid-2005
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