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Merck
CN

45661

Strychnine

PESTANAL®, analytical standard

Synonym(s):

(−)-Strychnine

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About This Item

Empirical Formula (Hill Notation):
C21H22N2O2
CAS Number:
57-24-9
Molecular Weight:
334.41
EC Number:
200-319-7
UNSPSC Code:
41116107
PubChem Substance ID:
329756875
Beilstein/REAXYS Number:
52979
MDL number:
MFCD00005941

Key Documents

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InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

grade

analytical standard

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

284-286 °C (lit.)

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

Quality Level

100

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General description

Strychnine is an alkaloid, available as a bioactive component in Semen Strychni, exhibiting analgesic, anti-inflammatory and anti-tumor effects. It is widely used in neurological research, treatment of genetic disorder nonketotic hyperglycinemia, treatment of stomach ailments, etc.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Strychnine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to electrospray ionization mass spectrometry.

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCBW8759

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Application of solid phase microextraction to the determination of strychnine in blood
Borroso.M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 29-34 (2005)
The 100 Most Important Chemical Compounds: A Reference Guide (2005)
Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry
Xu Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(2), 487-491 (2009)
Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing
Susanne Jonsson et al.
Neuropharmacology, 82, 69-75 (2014-04-02)
The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has
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