46109
Chloramphenicol palmitate
VETRANAL®, analytical standard
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About This Item
Empirical Formula (Hill Notation):
C27H42Cl2N2O6
CAS Number:
Molecular Weight:
561.54
EC Number:
208-477-9
UNSPSC Code:
41116107
PubChem Substance ID:
Beilstein/REAXYS Number:
2826438
MDL number:
InChI key
PXKHGMGELZGJQE-ILBGXUMGSA-N
InChI
1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
SMILES string
CCCCCCCCCCCCCCCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable, solid phase extraction (SPE): suitable
application(s)
clinical testing
format
neat
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Preparation Note
Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
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Warning
hcodes
Hazard Classifications
Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
涉药品监管产品
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M M de Villiers
Journal of pharmaceutical and biomedical analysis, 13(3), 191-198 (1995-03-01)
Particle size analysis results with respect to micronized, mean particle size below 10 microns, furosemide, chloramphenicol palmitate and acetaminophen particles are dealt with in this paper. Special consideration was given to the effect of the agglomeration of particles on data
W G Kramer et al.
Journal of clinical pharmacology, 24(4), 181-186 (1984-04-01)
The comparative bioavailability of chloramphenicol from intravenous succinate, oral palmitate, and oral base preparations was studied in a crossover manner in 12 adult patients. Chloramphenicol was administered at a dose of 1 Gm every 6 hours, and blood samples were
[Physical properties and availability of chloramphenicol palmitate in powdered mixtures containing microcrystalline cellulose].
R Cameroni et al.
Il Farmaco; edizione pratica, 39(3), 76-86 (1984-03-01)
Bioavailability and pharmacokinetics of chloramphenicol palmitate in malnourished children.
S Mahta et al.
The Indian journal of medical research, 74, 244-250 (1981-08-01)
R Kaliszan
Journal of pharmaceutical sciences, 75(2), 187-189 (1986-02-01)
Higher zeta-potential values were found for the crystalline particles of polymorph A when compared with polymorph B of chloramphenicol palmitate when measured at identical conditions. In the case of the thermomicroscopically prepared crystal sample being a mixture of the polymorphs
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