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Merck
CN

46160

Sigma-Aldrich

Evans Blue

Synonym(s):

Direct Blue 53

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About This Item

Empirical Formula (Hill Notation):
C34H24N6Na4O14S4
CAS Number:
314-13-6
Molecular Weight:
960.81
Colour Index Number:
23860
EC Number:
206-242-5
MDL number:
MFCD00004021
UNSPSC Code:
12171500
PubChem Substance ID:
24869872

Key Documents

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suitability

suitable for microscopy

SMILES string

[Na+].[Na+].[Na+].[Na+].Cc1cc(ccc1\N=N\c2ccc3c(cc(c(N)c3c2O)S([O-])(=O)=O)S([O-])(=O)=O)-c4ccc(\N=N\c5ccc6c(cc(c(N)c6c5O)S([O-])(=O)=O)S([O-])(=O)=O)c(C)c4

InChI

1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;

InChI key

ATNOAWAQFYGAOY-GPTZEZBUSA-J

Gene Information

human ... PTPN1(5770), PTPRF(5792)

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Carc. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Svitlana Garbuzova-Davis et al.
PloS one, 6(3), e16601-e16601 (2011-03-17)
Sanfilippo syndrome type B (MPS III B) is caused by a deficiency of α-N-acetylglucosaminidase enzyme, leading to accumulation of heparan sulfate within lysosomes and eventual progressive cerebral and systemic multiple organ abnormalities. However, little is known about the competence of
Zequan Yang et al.
American journal of respiratory cell and molecular biology, 40(3), 375-381 (2008-09-13)
Reactive oxygen species (ROS) play a crucial role in ischemia-reperfusion (IR) injury after lung transplantation. We hypothesized that NADPH oxidase derived from bone marrow (BM) cells contributes importantly to lung IR injury. An in vivo mouse model of lung IR
Fengshan Yu et al.
Journal of neurotrauma, 25(3), 184-195 (2008-03-21)
Matrix metalloproteinase-9 (MMP-9) activation plays an important role in blood-brain barrier (BBB) dysfunction after central nervous system injury. Oxidative stress is also implicated in the pathogenesis after cerebral ischemia and spinal cord injury (SCI), but the relationship between MMP-9 activation
Edward Htun van der Horst et al.
Neoplasia (New York, N.Y.), 10(4), 340-347 (2008-04-09)
Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers. Although MDK has been reported to act
Andrea L Moyer et al.
Investigative ophthalmology & visual science, 50(8), 3783-3793 (2009-03-07)
The purpose of this study was to determine to what extent blood-retinal barrier (BRB) permeability occurred during experimental Bacillus cereus endophthalmitis and whether tight junction alterations were involved in permeability. Mice were intravitreally injected with 100 colony-forming units of B.
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