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Merck
CN

46297

Furazolidone

VETRANAL®, analytical standard

Synonym(s):

3-(5-Nitrofurfurylideneamino)-2-oxazolidinone

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About This Item

Empirical Formula (Hill Notation):
C8H7N3O5
CAS Number:
Molecular Weight:
225.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-653-3
Beilstein/REAXYS Number:
8317414
MDL number:
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InChI key

PLHJDBGFXBMTGZ-WEVVVXLNSA-N

InChI

1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

SMILES string

[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-positive bacteria, parasites

application(s)

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

mode of action

enzyme | inhibits

Quality Level

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General description

Furazolidone is an effective antiprotozoal and antibacterial agent.

Application

Furazolidone may be used as a reference standard:
  • For the determination of the analyte in pharmaceutical formulations by second-derivative spectrophotometry.
  • For the determination of the analyte in animal feeds using liquid chromatography with ultraviolet and thermospray mass spectrometric detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Determination of furazolidone in animal feeds using liquid chromatography with UV and thermospray mass spectrometric detection.
McCracken RJ and Kennedy DG
Journal of Chromatography A, 771(1-2), 349- 354 (1997)
Formulation and advantages of furazolidone in liposomal drug delivery systems.
Alam MI, et al.
European Journal of Pharmaceutical Sciences, 84, 139- 145 (2016)
C V Prasad et al.
Journal of pharmaceutical and biomedical analysis, 21(5), 961-968 (2000-03-07)
A second-derivative spectrophotometric procedure has been developed for the simultaneous determination of tinidazole (TD), furazolidone (FD) and diloxanide furoate (DF) in a commercial preparation. The method consists of the utilization of second-derivative absorption spectra of tablet extract in distilled water
B H Ali
Veterinary research communications, 6(1), 1-11 (1983-01-01)
The pharmacological and toxicological properties of furazolidone have been briefly reviewed. Among the most important pharmacological actions of furazolidone is the inhibition of mono- and diamine oxidase activities, which seem to depend, at least in some species, on the presence
In vivo and in vitro metabolic studies of furazolidone: a risk evaluation.
L H Vroomen et al.
Drug metabolism reviews, 22(6-8), 663-676 (1990-01-01)

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