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47735

Forskolin

from Coleus forskohlii, ≥98.0% (TLC)

Synonym(s):

7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin

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About This Item

Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
66575-29-9
Molecular Weight:
410.50
EC Number:
266-410-9
UNSPSC Code:
41106305
MDL number:
MFCD00082317
Beilstein/REAXYS Number:
1692716
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biological source

Coleus forskohlii

assay

≥98.0% (TLC)

storage temp.

−20°C

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

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Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

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