47865
Fucoidan from Fucus vesiculosus
8-11% sulfur basis
Synonym(s):
Fucoidin
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About This Item
concentration
8-11% S
impurities
≤15% water
cation traces
Na: 7-8%
General description
Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.
polysaccharide, consists predominantly of sulfated L-fucose
Biochem/physiol Actions
Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.
Preparation Note
by a modification of the procedure of W.A.P. Black et al., J.Sci.Food.Agr. 3, 122 (1952)
Other Notes
Probe of polysaccharide binding to proacrosin
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R M Williams et al.
FEBS letters, 270(1-2), 168-172 (1990-09-17)
Sulphated polysaccharides and zona pellucida glycoproteins have been shown to bind non-enzymatically to proacrosin, the protein found within the acrosomal vesicle of mammalian spermatozoa. The mechanism of this interaction has been investigated using 125I-fucoidan to probe purified ram sperm proacrosin.