50430
Gly-Sar
puriss., ≥99.0% (T)
Synonym(s):
Glycyl-sarcosine
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About This Item
Linear Formula:
NH2CH2CON(CH3)CH2COOH
CAS Number:
Molecular Weight:
146.14
EC Number:
249-875-2
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1768450
MDL number:
grade
puriss.
assay
≥99.0% (T)
mp
198-202 °C (dec.)
SMILES string
CN(CC(O)=O)C(=O)CN
InChI
1S/C5H10N2O3/c1-7(3-5(9)10)4(8)2-6/h2-3,6H2,1H3,(H,9,10)
InChI key
VYAMLSCELQQRAE-UHFFFAOYSA-N
Gene Information
human ... SLC15A1(6564)
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.
Ina Hubatsch et al.
Journal of medicinal chemistry, 50(21), 5238-5242 (2007-09-25)
The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and
Zhiying Wang et al.
International journal of pharmaceutics, 441(1-2), 40-49 (2012-12-25)
The objective of this study is to delineate whether overexpression of human efflux transporters (P-gp, MRP2, and BCRP) in transfected MDCK cells affect the functional activities, and gene and protein expression of endogenous influx peptide transporter system (PepT). Real-time PCR
Qinghan Xu et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 650-657 (2013-01-15)
Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whether entecavir was a substrate of OAT1, OAT3, OCT, and PEPT1
Jian Cang et al.
Drug metabolism and pharmacokinetics, 25(5), 500-507 (2010-09-30)
To investigate the pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats, the pharmacokinetics of JBP485 were investigated in vivo both intravenously and orally. The effects of glycylsarcosine (Gly-Sar) on the uptake and transepithelial transport of JBP485 were examined
Dilara Jappar et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(12), 2250-2257 (2011-09-02)
This study evaluated the in vivo absorption and disposition of glycylsarcosine (GlySar), after escalating oral doses, in wild-type and peptide transporter 1 (Pept1) knockout mice. [(3)H]GlySar was administered to mice at doses of 1, 10, 100, 1000, and 5000 nmol/g
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 850303P-500MG | 04061835229925 |
| 850303P-25MG | 04061835229918 |
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