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Merck
CN

51020

Guanine

puriss., ≥99.0% (HPLC)

Synonym(s):

2-Amino-1,7-dihydro-6H-purin-6-one, 2-Amino-6-hydroxypurine, 2-Aminohypoxanthine

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About This Item

Empirical Formula (Hill Notation):
C5H5N5O
CAS Number:
Molecular Weight:
151.13
EC Number:
200-799-8
UNSPSC Code:
12352005
MDL number:
Beilstein/REAXYS Number:
9680
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grade

puriss.

assay

≥99.0% (HPLC)

ign. residue

≤0.3%

mp

>300 °C (lit.)

SMILES string

NC1=Nc2[nH]cnc2C(=O)N1

InChI

1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key

UYTPUPDQBNUYGX-UHFFFAOYSA-N

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pictograms

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signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Raja Chinnappan et al.
Nucleic acids research, 41(10), e106-e106 (2013-03-26)
Riboswitches are mRNA elements that specifically bind cellular metabolites and control gene expression by modifying their structure. As riboswitches often control essential genes in pathogenic bacteria, riboswitches have been proposed as new targets for antibiotics. High-throughput screening provides a powerful
Chee Khoon Lee et al.
Journal of the National Cancer Institute, 105(9), 595-605 (2013-04-19)
The epidermal growth factor receptor (EGFR) signaling pathway is crucial for regulating tumorigenesis and cell survival and may be important in the development and progression of non-small cell lung cancer (NSCLC). We examined the impact of EGFR-tyrosine kinase inhibitors (TKIs)
Alice T Shaw et al.
The New England journal of medicine, 368(25), 2385-2394 (2013-06-04)
In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior to standard chemotherapy with respect to efficacy is
Junichi Fukunaga et al.
RNA (New York, N.Y.), 19(7), 927-936 (2013-05-28)
AML1 (RUNX1) is a key transcription factor for hematopoiesis that binds to the Runt-binding double-stranded DNA element (RDE) of target genes through its N-terminal Runt domain. Aberrations in the AML1 gene are frequently found in human leukemia. To better understand
Wieneke A Buikhuisen et al.
The Lancet. Oncology, 14(6), 543-551 (2013-04-16)
Standard chemotherapy does not lead to long-term survival in patients with malignant pleural mesothelioma. Malignant pleural mesothelioma is strongly dependent on vasculature with high vessel counts and high concentrations of serum vascular growth factors. Thalidomide has shown antiangiogenic activity, and

Global Trade Item Number

SKUGTIN
186414-1G04061837613616
186414-5G04061838758156
186414-10X1G-N04061837613609
186414-5X5G-N04061837613623

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