52037
Herbimycin A from Streptomyces hygroscopicus
≥98.0% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C30H42N2O9
CAS Number:
Molecular Weight:
574.66
PubChem Substance ID:
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
4834067
MDL number:
assay
≥98.0% (HPLC)
solubility
acetonitrile: 0.2 mg/mL, clear, yellow
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
InChI
1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
InChI key
MCAHMSDENAOJFZ-BVXDHVRPSA-N
General description
Chemical structure: benzenoid
Biochem/physiol Actions
An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.
Other Notes
Inhibitor of protein-tyrosine kinases
Regulatory Information
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G Daoud et al.
Placenta, 29(10), 862-870 (2008-09-12)
Throughout gestation, fetal growth and development depend, in part, on placental transfer of nutrients from the maternal circulation. This latter function depends on multinucleated, terminally differentiated syncytiotrophoblasts. In vitro, freshly isolated cytotrophoblast cells differentiate spontaneously into syncytiotrophoblast in the presence
A L Burkhardt et al.
Current protocols in immunology, Chapter 11, Unit 11-Unit 11 (2008-04-25)
The tyrosine protein kinases are enzymes that are important in cellular signal transduction. Therefore, inhibition of TPKs provides an important means of investigating and potentially controlling many signaling pathways. The first basic protocol in this unit describes an assay of
Han-Jun Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 26(3), 273-280 (2010-08-28)
Hepatic fibrosis is associated with elevated sinusoidal pressure, which can be transmitted to the hepatic stellate cells (HSCs) in the perisinusoidal space of Disse. Here, we sought to determine the effects of pressure on cellular growth and Src-dependent signaling pathways