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Merck
CN

53633

Glabridin

analytical standard

Synonym(s):

(R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol

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About This Item

Empirical Formula (Hill Notation):
C20H20O4
CAS Number:
59870-68-7
Molecular Weight:
324.37
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329757962
MDL number:
MFCD03427694
Beilstein/REAXYS Number:
7141956

Key Documents

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InChI key

LBQIJVLKGVZRIW-ZDUSSCGKSA-N

SMILES string

CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c4ccc(O)cc4O

InChI

1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

512.6 °F - closed cup

flash_point_c

267 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF6975
BCCB2192
BCBZ3931
BCBF0498V
BCBF0498

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Itamar Yehuda et al.
Phytotherapy research : PTR, 25(5), 659-667 (2010-11-06)
The risk of death from cardiovascular diseases (CVDs), which are exacerbated by oxidative stress, is higher in diabetic women. This phenomenon has been attributed to the loss of estradiol-vascular protection. Such knowledge led us to examine the potential of glabridin
Jiyun Ahn et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 439-445 (2012-09-13)
Licorice (Glycyrrhiza glabra Linne) is a well-known medicinal plant and glabridin is an isoflavan isolated from licorice. In this study, we investigated the anti-obesity effect of glabridin and glabridin-rich supercritical fluid extract of licorice (LSC). Glabridin effectively inhibited adipogenesis in
Atiya Fatima et al.
Phytotherapy research : PTR, 23(8), 1190-1193 (2009-01-27)
Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 microg/mL.
Charlotte Simmler et al.
Fitoterapia, 90, 160-184 (2013-07-16)
Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening. While glabridin is one
Jee Youn Kim et al.
International immunopharmacology, 10(10), 1185-1193 (2010-07-17)
Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. Glabridin inhibited lipopolysaccharide-
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