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53787

Carazolol

Name: Carazolol
Brand: SIAL

analytical standard

Synonym(s):

1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol, 4-(2-Hydroxy-3-isopropylamino-propoxy)carbazole

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂N₂O₂

CAS Number:

57775-29-8

Molecular Weight:

298.38

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329757996

EC Number:

260-945-1

Beilstein/REAXYS Number:

3620576

MDL number:

MFCD00864588

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Properties

grade

analytical standard

Quality Level

200

assay

≥98.5% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable, solid phase extraction (SPE): suitable

mp

133-137 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12

InChI

1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3

InChI key

BQXQGZPYHWWCEB-UHFFFAOYSA-N

Description

General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706030, T706025

Application

Carazolol may be used as a reference standard for the determination of the analyte:

In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
In animal tissues by high-performance liquid chromatography with electrochemical detection.

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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CH/π hydrogen bonds play a role in ligand recognition and equilibrium between active and inactive states of the β2 adrenergic receptor: an ab initio fragment molecular orbital (FMO) study.

Tomonaga Ozawa et al.

Bioorganic & medicinal chemistry, 19(17), 5231-5237 (2011-08-09)

We examined CH/π hydrogen bonds using an ab initio fragment molecular orbital (FMO) method, combined with the CHPI program, to evaluate complexes of active (bound with agonist 1) and inactive (bound with inverse agonist 2) β2 adrenergic receptor (β(2)AR) states.

X-ray structure breakthroughs in the GPCR transmembrane region.

Sid Topiol et al.

Biochemical pharmacology, 78(1), 11-20 (2009-05-19)

G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled receptors in drug discovery. CRC Press; 2006] are the single largest drug target, representing 25-50% of marketed drugs [Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are

Structure of a beta1-adrenergic G-protein-coupled receptor.

Tony Warne et al.

Nature, 454(7203), 486-491 (2008-07-03)

G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 A resolution crystal structure of a beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol. The modified

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Global Trade Item Number

SKU	GTIN
T7383-25G	04061837372759
T3812-25G	04061834409748
1649991-50MG	04061838748430
T3812-5G	04061834409755
T7383-100G	04061833027479
1649991-100MG	04065272400268
PHR3140-100MG	04065266116533
53787-10MG	04061834391142

Key Documents

Carazolol

analytical standard

Select a Size

About This Item

grade

Quality Level

assay

technique(s)

mp

application(s)

format

storage temp.

SMILES string

InChI

InChI key

General description

Application

Packaging

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number